Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 장은경 | - |
dc.date.accessioned | 2019-04-22T02:48:49Z | - |
dc.date.available | 2019-04-22T02:48:49Z | - |
dc.date.issued | 2016-12 | - |
dc.identifier.citation | Immune Network, v. 16, Issue 6, Page. 366-372 | en_US |
dc.identifier.issn | 1598-2629 | - |
dc.identifier.issn | 2092-6685 | - |
dc.identifier.uri | https://synapse.koreamed.org/DOIx.php?id=10.4110/in.2016.16.6.366 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/102374 | - |
dc.description.abstract | K/BxN serum can induce arthritis in normal mice because of abundant autoantibodies that trigger an innate inflammatory response in joints. To determine whether IL-17 is involved in the pathogenesis of serum-induced arthritis, we injected wild-type and IL-17–/– mice with K/BxN serum and evaluated them for signs of arthritis. Unlike wild-type mice, IL-17–/– mice did not show any signs of arthritis. IL-17 was produced predominantly by CD3– CD4– gdTCR– NK1.1– Sca1int Thy1hi cells residing in the inflamed synovial tissue. When synovial cells extracted from normal joints were stimulated with IL-23 or autoantibody-containing immune complexes, a substantial fraction of Sca1int Thy1hi cells produced IL-17. Thus, we have identified a novel population of IL-17-producing innate synovial cells that play a crucial role in the development of K/BxN serum-induced arthritis. | en_US |
dc.description.sponsorship | This work was supported by a NRF grant funded by the Ministry of Science, ICT & Future Planning (NRF-2014R1A2A1A11052070 awarded to J. Youn). | en_US |
dc.language.iso | en | en_US |
dc.publisher | 대한면역학회 | en_US |
dc.subject | IL-17 | en_US |
dc.subject | Synovial cells | en_US |
dc.subject | Arthritis | en_US |
dc.subject | Immune complex | en_US |
dc.title | Interleukin 17-expressing Innate Synovial Cells Drive K/BxN Serum-induced Arthritis | en_US |
dc.type | Article | en_US |
dc.relation.no | 6 | - |
dc.relation.volume | 16 | - |
dc.identifier.doi | 10.4110/in.2016.16.6.366 | - |
dc.relation.page | 366-372 | - |
dc.relation.journal | Immune Network | - |
dc.contributor.googleauthor | Cho, Wang Shik | - |
dc.contributor.googleauthor | Jang, Eunkyeong | - |
dc.contributor.googleauthor | Kim, Ho-Youn | - |
dc.contributor.googleauthor | Youn, Jeehee | - |
dc.relation.code | 2016018947 | - |
dc.sector.campus | S | - |
dc.sector.daehak | RESEARCH INSTITUTE[S] | - |
dc.sector.department | INSTITUTE FOR THE INTERGRATION OF MEDICINE AND INNOVATIVE TECHNOLOGY | - |
dc.identifier.pid | virgo21 | - |
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