Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 최한곤 | - |
dc.date.accessioned | 2019-04-11T04:22:28Z | - |
dc.date.available | 2019-04-11T04:22:28Z | - |
dc.date.issued | 2015-09 | - |
dc.identifier.citation | INTERNATIONAL JOURNAL OF NANOMEDICINE, v. 10, Page. 5249-5262 | en_US |
dc.identifier.issn | 1178-2013 | - |
dc.identifier.uri | https://www.dovepress.com/tumor-targeting-ph-sensitive-nanoparticles-for-docetaxel-delivery-to-d-peer-reviewed-article-IJN | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/101691 | - |
dc.description.abstract | The attachment of polyethylene glycol (PEG) increases the circulation time of drug-containing nanoparticles; however, this also negatively affects cellular uptake. To overcome this problem, unique lipid polymer hybrid (LPH) nanoparticles were developed with a pH-responsive PEG layer that detached prior to cell uptake. Docetaxel (DTX) was incorporated into the lipid core of the nanoparticles, which was then shielded with the pH-responsive block co-polymer polyethylene glycol-b-polyaspartic acid (PEG-b-PAsp) using a modified emulsion method. The optimized LPH nanoparticles were similar to 200 nm and had a narrow size distribution. Drug release from DTX-loaded LPH (DTX-LPH) nanoparticles was pH-sensitive, which is beneficial for tumor targeting. More importantly, DTX-LPH nanoparticles were able to effectively induce apoptosis in cancer cells. The negative surface charge and PEG shell of vehicle remarkably enhanced the blood circulation and physiological activity of DTX-LPH nanoparticles compared with that of free DTX. The nanoparticles were also found to reduce the size of tumors in tumor-bearing xenograft mice. The in vivo anticancer effect of DTX-LPH nanoparticles was further confirmed by the elevated levels of caspase-3 and poly ADP ribose polymerase found in the tumors after treatment. Thus, the results suggest that this novel LPH system could be an effective new treatment for cancer. | en_US |
dc.description.sponsorship | This research was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIP) (No 2015R1A2A2A01004118, 2015R1A2A2A04004806). | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | DOVE MEDICAL PRESS LTD | en_US |
dc.subject | docetaxel | en_US |
dc.subject | polyaspartic acid | en_US |
dc.subject | drug delivery systems | en_US |
dc.subject | antitumor | en_US |
dc.subject | pH-sensitive | en_US |
dc.subject | SOLID LIPID NANOPARTICLES | en_US |
dc.subject | POLYMER HYBRID NANOPARTICLES | en_US |
dc.subject | ANTICANCER DRUG | en_US |
dc.subject | CO-DELIVERY | en_US |
dc.subject | IN-VITRO | en_US |
dc.subject | CATIONIC NANOPARTICLES | en_US |
dc.subject | ANTITUMOR EFFICACY | en_US |
dc.subject | INHIBITOR P27 | en_US |
dc.subject | BREAST-CANCER | en_US |
dc.subject | THERAPY | en_US |
dc.title | Tumor-targeting, pH-sensitive nanoparticles for docetaxel delivery to drug-resistant cancer cells | en_US |
dc.type | Article | en_US |
dc.relation.volume | 10 | - |
dc.identifier.doi | 10.2147/IJN.S89584 | - |
dc.relation.page | 5249-5262 | - |
dc.relation.journal | INTERNATIONAL JOURNAL OF NANOMEDICINE | - |
dc.contributor.googleauthor | Tran, TH | - |
dc.contributor.googleauthor | Ramasamy, T | - |
dc.contributor.googleauthor | Choi, JY | - |
dc.contributor.googleauthor | Nguyen, HT | - |
dc.contributor.googleauthor | Pham, TT | - |
dc.contributor.googleauthor | Jeong, JH | - |
dc.contributor.googleauthor | Ku, SK | - |
dc.contributor.googleauthor | Choi, HG | - |
dc.contributor.googleauthor | Yong, CS | - |
dc.contributor.googleauthor | Kim, JO | - |
dc.relation.code | 2015000551 | - |
dc.sector.campus | E | - |
dc.sector.daehak | COLLEGE OF PHARMACY[E] | - |
dc.sector.department | DEPARTMENT OF PHARMACY | - |
dc.identifier.pid | hangon | - |
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