The Benefits of Combination Therapy with Esomeprazole and Rebamipide in Symptom Improvement in Reflux Esophagitis: An International Multicenter Study
- Title
- The Benefits of Combination Therapy with Esomeprazole and Rebamipide in Symptom Improvement in Reflux Esophagitis: An International Multicenter Study
- Author
- 이항락
- Keywords
- Peptic esophagitis; Symptoms; Heartburn; Rebamipide; Esomeprazole
- Issue Date
- 2016-11
- Publisher
- EDITORIAL OFFICE GUT & LIVER
- Citation
- GUT AND LIVER, v. 10, NO 6, Page. 910-916
- Abstract
- Background/Aims: To investigate the effects of esomeprazole and rebamipide combination therapy on symptomatic improvement in patients with reflux esophagitis. Methods: A total of 501 patients with reflux esophagitis were randomized into one of the following two treatment regimens: 40 mg esomeprazole plus 300 mg rebamipide daily (combination therapy group) or 40 mg esomeprazole daily (monotherapy group). We used a symptom questionnaire that evaluated heartburn, acid regurgitation, and four upper gastrointestinal symptoms. The primary efficacy end point was the mean decrease in the total symptom score. Results: The mean decreases in the total symptom score at 4 weeks were estimated to be -18.1 +/- 13.8 in the combination therapy group and -15.1 +/- 11.9 in the monotherapy group (p=0.011). Changes in reflux symptoms from baseline after 4 weeks of treatment were -8.4 +/- 6.6 in the combination therapy group and -6.8 +/- 5.9 in the monotherapy group (p=0.009). Conclusions: Over a 4-week treatment course, esomeprazole and rebamipide combination therapy was more effective in decreasing the symptoms of reflux esophagitis than esomeprazole monotherapy.
- URI
- http://www.gutnliver.org/journal/view.html?doi=10.5009/gnl15537https://repository.hanyang.ac.kr/handle/20.500.11754/101257
- ISSN
- 1976-2283; 2005-1212
- DOI
- 10.5009/gnl15537
- Appears in Collections:
- COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
- Files in This Item:
- The Benefits of Combination Therapy with Esomeprazole and Rebamipide in Symptom Improvement in Reflux Esophagitis.pdfDownload
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