Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이항락 | - |
dc.date.accessioned | 2019-03-27T05:36:18Z | - |
dc.date.available | 2019-03-27T05:36:18Z | - |
dc.date.issued | 2016-11 | - |
dc.identifier.citation | GUT AND LIVER, v. 10, NO 6, Page. 910-916 | en_US |
dc.identifier.issn | 1976-2283 | - |
dc.identifier.issn | 2005-1212 | - |
dc.identifier.uri | http://www.gutnliver.org/journal/view.html?doi=10.5009/gnl15537 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/101257 | - |
dc.description.abstract | Background/Aims: To investigate the effects of esomeprazole and rebamipide combination therapy on symptomatic improvement in patients with reflux esophagitis. Methods: A total of 501 patients with reflux esophagitis were randomized into one of the following two treatment regimens: 40 mg esomeprazole plus 300 mg rebamipide daily (combination therapy group) or 40 mg esomeprazole daily (monotherapy group). We used a symptom questionnaire that evaluated heartburn, acid regurgitation, and four upper gastrointestinal symptoms. The primary efficacy end point was the mean decrease in the total symptom score. Results: The mean decreases in the total symptom score at 4 weeks were estimated to be -18.1 +/- 13.8 in the combination therapy group and -15.1 +/- 11.9 in the monotherapy group (p=0.011). Changes in reflux symptoms from baseline after 4 weeks of treatment were -8.4 +/- 6.6 in the combination therapy group and -6.8 +/- 5.9 in the monotherapy group (p=0.009). Conclusions: Over a 4-week treatment course, esomeprazole and rebamipide combination therapy was more effective in decreasing the symptoms of reflux esophagitis than esomeprazole monotherapy. | en_US |
dc.description.sponsorship | This research was supported by a grant from the Korean College of Helicobater and Upper Gastrointestinal Research (UMIN000005602). | en_US |
dc.language.iso | en | en_US |
dc.publisher | EDITORIAL OFFICE GUT & LIVER | en_US |
dc.subject | Peptic esophagitis | en_US |
dc.subject | Symptoms | en_US |
dc.subject | Heartburn | en_US |
dc.subject | Rebamipide | en_US |
dc.subject | Esomeprazole | en_US |
dc.title | The Benefits of Combination Therapy with Esomeprazole and Rebamipide in Symptom Improvement in Reflux Esophagitis: An International Multicenter Study | en_US |
dc.type | Article | en_US |
dc.relation.no | 6 | - |
dc.relation.volume | 10 | - |
dc.identifier.doi | 10.5009/gnl15537 | - |
dc.relation.page | 910-916 | - |
dc.relation.journal | GUT AND LIVER | - |
dc.contributor.googleauthor | Hong, Su Jin | - |
dc.contributor.googleauthor | Park, Soo-Heon | - |
dc.contributor.googleauthor | Moon, Jeong Seop | - |
dc.contributor.googleauthor | Shin, Woon Geon | - |
dc.contributor.googleauthor | Kim, Jae Gyu | - |
dc.contributor.googleauthor | Lee, Yong Chan | - |
dc.contributor.googleauthor | Lee, Dong Ho | - |
dc.contributor.googleauthor | Jang, Jae Young | - |
dc.contributor.googleauthor | Kim, Jae J. | - |
dc.contributor.googleauthor | Lee, Hang-Lak | - |
dc.relation.code | 2016005405 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | alwayshang | - |
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