Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 백승삼 | - |
dc.date.accessioned | 2019-02-12T07:10:05Z | - |
dc.date.available | 2019-02-12T07:10:05Z | - |
dc.date.issued | 2016-10 | - |
dc.identifier.citation | Journal of Pathology and Translational Medicine, v. 50, NO. 5, Page. 327-336 | en_US |
dc.identifier.issn | 2383-7837 | - |
dc.identifier.issn | 2383-7845 | - |
dc.identifier.uri | https://www.jpatholtm.org/journal/view.php?doi=10.4132/jptm.2016.06.22 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/98896 | - |
dc.description.abstract | Background: Developing predictive markers for hepatocellular carcinoma (HCC) is important, because many patients experience recurrence and metastasis. Epithelial to mesenchymal transition (EMT) is a developmental process that plays an important role during embryogenesis and also during cancer metastasis. Paired-related homeobox protein 1 (Prrx-1) is an EMT inducer that has recently been introduced, and its prognostic significance in HCC is largely unknown. Methods: Tissue microarray was constructed using surgically resected primary HCCs from 244 cases. Immunohistochemical staining of E-cadherin and Prrx-1 was performed. The correlation between E-cadherin loss and Prrx-1 expression, as well as other clinicopathologic factors, was evaluated. Results: E-cadherin expression was decreased in 96 cases (39.4%). Loss of E-cadherin correlated with a higher recurrence rate (p < .001) but was not correlated with patient's survival. Thirty-two cases (13.3%) showed at least focal nuclear Prrx-1 immunoreactivity while all non-neoplastic livers (n = 22) were negative. Prrx-1 expression was not associated with E-cadherin loss, survival or recurrence rates, pathologic factors, or the Ki-67 labeling index. Twenty tumors that were positive for E-cadherin and Prrx-1 had significantly higher nuclear grades than the rest of the cohort (p = .037). In Cox proportional hazard models, E-cadherin loss and large vessel invasion were independent prognostic factors for shorter disease-free survival. Cirrhosis and high Ki-67 index (> 40%) were independent prognostic factors for shorter overall survival. Conclusions: Prrx-1 was expressed in small portions of HCCs but not in normal livers. Additional studies with a large number of Prrx-1-positive cases are required to confirm the results of this study. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Korean Society of Pathologists | en_US |
dc.subject | Liver | en_US |
dc.subject | Neoplasms | en_US |
dc.subject | Epithelial-mesenchymal transition | en_US |
dc.subject | Prrx-1 protein | en_US |
dc.title | Clinicopathologic Correlations of E-cadherin and Prrx-1 Expression Loss in Hepatocellular Carcinoma | en_US |
dc.type | Article | en_US |
dc.relation.no | 5 | - |
dc.relation.volume | 50 | - |
dc.identifier.doi | 10.4132/jptm.2016.06.22 | - |
dc.relation.page | 327-336 | - |
dc.relation.journal | Journal of Pathology and Translational Medicine | - |
dc.contributor.googleauthor | Yi, Kijong | - |
dc.contributor.googleauthor | Kim, Hyunsung | - |
dc.contributor.googleauthor | Chung, Yumin | - |
dc.contributor.googleauthor | Ahn, Hyein | - |
dc.contributor.googleauthor | Sim, Jongmin | - |
dc.contributor.googleauthor | Wi, Young Chan | - |
dc.contributor.googleauthor | Pyo, Ju Yeon | - |
dc.contributor.googleauthor | Song, Young-Soo | - |
dc.contributor.googleauthor | Paik, Seung Sam | - |
dc.contributor.googleauthor | Oh, Young-Ha | - |
dc.relation.code | 2016032826 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | sspaik | - |
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