Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 문효방 | - |
dc.date.accessioned | 2019-01-09T04:53:43Z | - |
dc.date.available | 2019-01-09T04:53:43Z | - |
dc.date.issued | 2018-06 | - |
dc.identifier.citation | SCIENCE OF THE TOTAL ENVIRONMENT, v. 627, Page. 506-513 | en_US |
dc.identifier.issn | 0048-9697 | - |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S0048969718301475 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/81163 | - |
dc.description.abstract | Several studies suggested potential links of phthalates to stress-related outcomes. However, limited evidence has been available for the relationships between phthalate metabolites and free cortisol and 8-hydroxy-2'-deoxyguanosine (8-OHdG) in perinatal and postnatal environments. Therefore, we evaluated the relationships between phthalate metabolites and free cortisol and 8-OHdG in mother-child pairs. We repeatedly collected urine samples of 287 mother-child pairs from just before delivery to 15 months of age to measure the levels of four phthalate metabolites - mono-(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP), mono-(2-ethyl-5-oxohexyl) phthalate (MEOHP), mono-isobutyl phthalate (MiBP), and mono-n-butyl phthalate (MnBP) - and free cortisol and 8-OHdG. We used linear mixed effect models and generalized additive mixed models to estimate the relationship between the phthalate metabolites and free cortisol and 8-OHdG after adjusting for the child's gender, urine collection time, and maternal smoking status. The four phthalate metabolite levels were strongly correlated each other (all, p < .0001), and intra-class correlation for each metabolite in children ranged from 0.18 to 0.96. All four phthalate metabolites were positively associated with both free cortisol (MEHHP, beta = 0.18 and p < .0001; MEOHP, beta=0.17 and p < .0001; MiBP, beta = 0.13 and p=.0001; MnBP, beta = 0.21 and p < .0001; and molar sum of metabolites, beta=0.21 and p < .0001) and 8-OHdG ( MEHHP, beta=0.20 and p<.0001; MEOHP, beta=0.18 and p<.0001; MiBP, beta=0.23 and p<.0001; MnBP, beta=0.28 and p<.0001; and molar sum of metabolites, beta = 0.29 and p<.0001) in childhood. Our findings suggest that phthalate exposures increase free cortisol and 8-OHdG levels in early childhood. (C) 2018 Elsevier B.V. All rights reserved. | en_US |
dc.description.sponsorship | This study was supported by the Korea Food and Drug Administration (12162KFDA731) and the Basic Science Research Program (2016R1D1A1B03932315) and BK21 PLUS (22A20130012682) through the National Research Foundation of Korea (NRF) funded by the Ministry of Education. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | ELSEVIER SCIENCE BV | en_US |
dc.subject | Phthalate metabolites | en_US |
dc.subject | Free cortisol | en_US |
dc.subject | 8-Hydroxy-2 '-deoxyguanosine (8-OHdG) | en_US |
dc.subject | Mother-child pairs | en_US |
dc.title | Association of phthalate exposures with urinary free cortisol and 8-hydroxy-2 '-deoxyguanosine in early childhood | en_US |
dc.type | Article | en_US |
dc.relation.volume | 627 | - |
dc.identifier.doi | 10.1016/j.scitotenv.2018.01.125 | - |
dc.relation.page | 506-513 | - |
dc.relation.journal | SCIENCE OF THE TOTAL ENVIRONMENT | - |
dc.contributor.googleauthor | Kim, Jin Hee | - |
dc.contributor.googleauthor | Lee, Jangwoo | - |
dc.contributor.googleauthor | Moon, Hyo-Bang | - |
dc.contributor.googleauthor | Park, Jeongim | - |
dc.contributor.googleauthor | Choi, Kyungho | - |
dc.contributor.googleauthor | Kim, Sung Koo | - |
dc.contributor.googleauthor | Kim, Sungkyoon | - |
dc.relation.code | 2018000216 | - |
dc.sector.campus | E | - |
dc.sector.daehak | COLLEGE OF SCIENCE AND CONVERGENCE TECHNOLOGY[E] | - |
dc.sector.department | DEPARTMENT OF MARINE SCIENCE AND CONVERGENCE ENGINEERING | - |
dc.identifier.pid | hbmoon | - |
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