2D Transition Metal Dichalcogenides with Glucan Multivalency for Antibody-free Pathogen Recognition
- Title
- 2D Transition Metal Dichalcogenides with Glucan Multivalency for Antibody-free Pathogen Recognition
- Author
- 김종호
- Keywords
- INITIO MOLECULAR-DYNAMICS; TOTAL-ENERGY CALCULATIONS; AUGMENTED-WAVE METHOD; ESCHERICHIA-COLI; MONOLAYER MOS2; BASIS-SET; EXFOLIATION; NANOSHEETS; WS2; PHOTOLUMINESCENCE
- Issue Date
- 2018-06
- Publisher
- NATURE PUBLISHING GROUP
- Citation
- NATURE COMMUNICATIONS, v. 9, Article no. 2549
- Abstract
- The ability to control the dimensions and properties of nanomaterials is fundamental to the creation of new functions and improvement of their performances in the applications of interest. Herein, we report a strategy based on glucan multivalent interactions for the simultaneous exfoliation and functionalization of two-dimensional transition metal dichal-cogenides (TMDs) in an aqueous solution. The multivalent hydrogen bonding of dextran with bulk TMDs (WS2, WSe2, and MoSe2) in liquid exfoliation effectively produces TMD monolayers with binding multivalency for pathogenic bacteria. Density functional theory simulation reveals that the multivalent hydrogen bonding between dextran and TMD monolayers is very strong and thermodynamically favored (Delta E-b = -0.52 eV). The resulting dextran/TMD hybrids (dex-TMDs) exhibit a stronger affinity (K-d = 11 nM) to Escherichia coli O157:H7 (E. coli) than E. coli-specific antibodies and aptamers. The dex-TMDs can effectively detect a single copy of E. coli based on their Raman signal.
- URI
- https://www.nature.com/articles/s41467-018-04997-whttps://repository.hanyang.ac.kr/handle/20.500.11754/81098
- ISSN
- 2041-1723
- DOI
- 10.1038/s41467-018-04997-w
- Appears in Collections:
- COLLEGE OF ENGINEERING SCIENCES[E](공학대학) > MATERIALS SCIENCE AND CHEMICAL ENGINEERING(재료화학공학과) > Articles
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