Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 문효방 | - |
dc.date.accessioned | 2018-12-20T08:02:36Z | - |
dc.date.available | 2018-12-20T08:02:36Z | - |
dc.date.issued | 2018-03 | - |
dc.identifier.citation | SCIENCE OF THE TOTAL ENVIRONMENT, v. 616, Page. 510-516 | en_US |
dc.identifier.issn | 0048-9697 | - |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S004896971732510X | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/80983 | - |
dc.description.abstract | Many scientists made estimates of the body burden of PBDEs from breastmilk and house dust. Interestingly, they have not included the prenatal contribution to the body burden in young children after birth. In order to address how the prenatal contribution is important in the risk assessment of PBDEs in infants up to five years old, we used the median measurements of BDE-47 as a model chemical in 108 neonates in Korea, and made simulations of its disposition out of body from birth to five years. During the simulation periods, the environmental exposure was considered for house dust, babyfood, breastmilk consumption, etc., with assumption of typical exposure scenario applicable to general infants in Korea. About 22% of the total amounts of BDE-47 in newborn remained up to 5 years after birth. The relative amounts of BDE-47 from the prenatal source were 20%, 14%, 10%, 8%, 6%, and 4% of the total body burden for 1-, 2-, 3-, 4- and 5-year after birth, respectively. The contribution from breastfeeding was 95.2% and 92.2% of the total postnatal exposure amounts at 6-month and 1-year after birth, respectively. After cease of breastfeeding at 1-yr, house dust and food were the important sources of exposure up to 5-yr; however, their contributions to the bodyburden were negligible with consideration of the remaining amounts of the analytes from the breastmilk and prenatal exposure. Suggestively, the innate amounts and pharmacokinetics should be counted in estimating bodyburden of BDE-47. (c) 2017 Published by Elsevier B.V. | en_US |
dc.description.sponsorship | This study was supported by the Ministry of Environment (MoE) of Korea (#2015001940003), National Research Foundation of Korea (BK21 PLUS), Ministry of Food and Drug Safety (12162KFDA731) and 2016 Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT and Future Planning (2016R1A2B4015646). | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | ELSEVIER SCIENCE BV | en_US |
dc.subject | 2,2 ',4,4 '-tetrabromodiphenyl ether (BDE-47) | en_US |
dc.subject | Placental transfer | en_US |
dc.subject | PBPK | en_US |
dc.subject | Exposure assessment | en_US |
dc.subject | Innate amounts | en_US |
dc.title | Prenatal contribution of 2, 2 ', 4, 4 '-tetrabromodiphenyl ether (BDE-47) to total body burden in young children | en_US |
dc.type | Article | en_US |
dc.relation.volume | 616 | - |
dc.identifier.doi | 10.1016/j.scitotenv.2017.09.161 | - |
dc.relation.page | 510-516 | - |
dc.relation.journal | SCIENCE OF THE TOTAL ENVIRONMENT | - |
dc.contributor.googleauthor | Shin, Mi-Yeon | - |
dc.contributor.googleauthor | Kim, Sunmi | - |
dc.contributor.googleauthor | Lee, Sunggyu | - |
dc.contributor.googleauthor | Kim, Hai-Joong | - |
dc.contributor.googleauthor | Lee, Jeong Jae | - |
dc.contributor.googleauthor | Choi, Gyuyeon | - |
dc.contributor.googleauthor | Choi, Sooran | - |
dc.contributor.googleauthor | Kim, Sungjoo | - |
dc.contributor.googleauthor | Kim, Su Young | - |
dc.contributor.googleauthor | Moon, Hyo-Bang | - |
dc.contributor.googleauthor | Park, Jeongim | - |
dc.contributor.googleauthor | Choi, Kyungho | - |
dc.contributor.googleauthor | Kim, Sungkyoon | - |
dc.relation.code | 2018000216 | - |
dc.sector.campus | E | - |
dc.sector.daehak | COLLEGE OF SCIENCE AND CONVERGENCE TECHNOLOGY[E] | - |
dc.sector.department | DEPARTMENT OF MARINE SCIENCE AND CONVERGENCE ENGINEERING | - |
dc.identifier.pid | hbmoon | - |
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