Protein expression pattern of murine macrophages treated with anthrax lethal toxin

Title
Protein expression pattern of murine macrophages treated with anthrax lethal toxin
Author
이정호
Keywords
Bacillus anthracis; Protein expression profiling; Two-dimensional polyacrylamide gel electrophoresis; MALDI-TOF; Murine macrophages; Lethal toxin
Issue Date
2008-07
Publisher
ELSEVIER SCIENCE BV
Citation
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, v. 1784, No. 11, Page. 1501-1506
Abstract
Anthrax lethal toxin (LeTx; a combination of protective antigen and lethal factor) secreted by the vegetative cells of Bacillus anthracis is cytotoxic for certain macrophage cell lines. The role of LeTx in mediating these effects is complicated largely due to the difficulty in identifying and assigning functions to the affected proteins. To analyze the protein profile of murine macrophages treated with LeTx, we employed two-dimensional polyacrylamide gel electrophoresis and MALDI-TOF MS, and interpreted the peptide mass fingerprint data relying on the ProFound database. Among the differentially expressed spots, cleaved mitogen-activated protein kinase kinase 1 acting as a negative element in the signal transduction pathway, and glucose-6-phosphate dehydrogenase playing a rote in the protection of cells from hyperproduction of active oxygen were up-regulated in the LeTx-treated macrophages. (C) 2008 Elsevier B.V. All rights reserved.
URI
https://www.sciencedirect.com/science/article/pii/S1570963908002070http://repository.hanyang.ac.kr/handle/20.500.11754/80578
ISSN
1570-9639
DOI
10.1016/j.bbapap.2008.06.016
Appears in Collections:
COLLEGE OF ENGINEERING SCIENCES[E](공학대학) > MATERIALS SCIENCE AND CHEMICAL ENGINEERING(재료화학공학과) > Articles
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