Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 김성민 | - |
dc.date.accessioned | 2018-09-04T12:11:42Z | - |
dc.date.available | 2018-09-04T12:11:42Z | - |
dc.date.issued | 2011-09 | - |
dc.identifier.citation | INTERNATIONAL JOURNAL OF HYPERTHERMIA, Vol.27, No.5 [2011], p445-452 | en_US |
dc.identifier.issn | 0265-6736 | - |
dc.identifier.uri | https://www.tandfonline.com/doi/abs/10.3109/02656736.2011.569967?journalCode=ihyt20 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/74912 | - |
dc.description.abstract | Purpose: Hyperthermia-induced apoptosis is mediated by mitochondrial pathway, and is temporally correlated with alterations in mitochondrial morphology in neuroepithelial cells. In addition, regular exercise up-regulates heat shock proteins (HSPs) that inhibit apoptosis. However, embryo-protective effects of maternal exercise against heat exposure during pregnancy have not been fully understood yet.Materials and methods: To investigate the role of maternal exercise in protecting embryos from hyperthermia, we measured apoptosis-related factors and HSPs in Hsp70 knockout mouse embryos. Pregnant mice were divided into control, exercise, hyperthermia-after-exercise, and hyperthermia groups. Where appropriate the swimming exercise was performed for 5-10 min/day from embryonic day (ED) 1 to ED 8, and hyperthermia (43 degrees C, 5 min) was induced on ED 8. To characterise the effects of maternal exercise on apoptosis-related factors and HSPs, we performed western blotting and transmission electron microscopy.Results: Caspase-9, -7, -3 and Bax were down-regulated in the hyperthermia-after-exercise group and Bcl-2, Hsp27 and Hsp110 were up-regulated. The number of apoptotic cells was markedly reduced in the hyperthermia-after-exercise group.Conclusions: Maternal exercise plays an important role in inhibiting apoptotic cell death in embryos against hyperthermic exposure during pregnancy. | en_US |
dc.description.sponsorship | This work was supported by the Korea Research Foundation Grant funded by the Korean Government (MOEHRD, Basic Research Promotion Fund) (KRF-2007-000-0000-5739). The authors alone are responsible for the content and writing of the paper. | en_US |
dc.language.iso | en | en_US |
dc.publisher | TAYLOR & FRANCIS LTD, 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND | en_US |
dc.subject | maternal hyperthermia | en_US |
dc.subject | maternal exercise | en_US |
dc.subject | apoptosis | en_US |
dc.subject | heat shock proteins | en_US |
dc.subject | Hsp70 knockout (KO) mouse embryos | en_US |
dc.title | Maternal exercise reduces hyperthermia-induced apoptosis in developing mouse brain | en_US |
dc.type | Article | en_US |
dc.relation.no | 5 | - |
dc.relation.volume | 27 | - |
dc.identifier.doi | 10.3109/02656736.2011.569967 | - |
dc.relation.page | 445-452 | - |
dc.relation.journal | INTERNATIONAL JOURNAL OF HYPERTHERMIA | - |
dc.contributor.googleauthor | Lee, Jin | - |
dc.contributor.googleauthor | Cho, Joon-Yong | - |
dc.contributor.googleauthor | Oh, Sang-Duk | - |
dc.contributor.googleauthor | Kim, Sung-Min | - |
dc.contributor.googleauthor | Shim, Yun-Taek | - |
dc.contributor.googleauthor | Park, Sok | - |
dc.contributor.googleauthor | Kim, Won-Kyu | - |
dc.relation.code | 2011204225 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF PERFORMING ARTS AND SPORT[S] | - |
dc.sector.department | DEPARTMENT OF PHYSICAL EDUCATION | - |
dc.identifier.pid | minarthur | - |
dc.identifier.researcherID | 57031005200 | - |
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