Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 이현규 | - |
dc.date.accessioned | 2018-08-22T05:08:53Z | - |
dc.date.available | 2018-08-22T05:08:53Z | - |
dc.date.issued | 2016-07 | - |
dc.identifier.citation | JOURNAL OF GINSENG RESEARCH, Page. 237-244 | en_US |
dc.identifier.issn | 1226-8453 | - |
dc.identifier.issn | 2093-4947 | - |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S1226845315000779?via%3Dihub | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/74472 | - |
dc.description.abstract | Background Ginsenoside Rg3 and arginine–fructose (Arg-Fru) are known as the hypotensive compounds of Panax ginseng; however, their efficacy on antihypertension has not been reported yet to our best knowledge. Thus, hypotensive components-enriched fraction of red ginseng (HCEF-RG) was prepared from fine root concentrate (FR) and their antihypertensive effects were investigated in spontaneously hypertensive rats (SHR). Methods Male SHRs were divided into six groups: control (Wistar Kyoto, SHR); FR 500; FR 1,000; HCEF-RG 500; and HCEF-RG 1,000; samples (mg/kg body weight) were orally administered every day for 8 wk. Blood pressure was monitored at 1 wk, 2 wk, 3 wk, 4 wk, 6 wk, and 8 wk by tail cuff method. At 8 wk after samples administration, mice were killed for the measurement of renin activity (RA), angiotensin-I converting enzyme inhibition, angiotensin II, and nitric oxide (NO) levels in plasma. Results HCEF-RG with four-fold more Rg3 and 24-fold more Arg-Fru contents was successfully prepared from reacted mixtures of FR and persimmon vinegar (12 times against FR, v/v) at 80°C for 18 h. Both FR 1,000 and HCEF-RG 1,000 showed lowered systolic blood pressure than SHR control group and HCEF-RG 1,000 group exhibited a significant decrease in diastolic blood pressure. RA was significantly lowered in all treated groups, while angiotensin II did not affect by FR and HCEF-RG treatment. However, angiotensin-I converting enzyme inhibition and NO in FR 1,000 and HCEF-RG 1,000 were significantly increased compared with SHR control group. Conclusion HCEF-RG is more effective and useful for alleviating hypertension than FR, implying the health benefit of Rg3 and Arg-Fru. | en_US |
dc.description.sponsorship | This work was supported by Convergence Technology Development Program of Agriculture, Industry and Commerce (2011) through the Korea Technology and Information Promotion Agency funded by Small and Medium Business Administration (S2042340) of Korea. | en_US |
dc.language.iso | en | en_US |
dc.publisher | KOREAN SOC GINSENG | en_US |
dc.subject | arginine-fructose | en_US |
dc.subject | blood pressure | en_US |
dc.subject | ginsenoside Rg3 | en_US |
dc.subject | hypotensive components-enriched | en_US |
dc.subject | Korean Red Ginseng | en_US |
dc.title | Anti-hypertensive effect of Korean red ginseng by enrichment of ginsenoside Rg3 and arginine-fructose | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.1016/j.jgr.2015.08.002 | - |
dc.relation.page | 237-244 | - |
dc.relation.journal | JOURNAL OF GINSENG RESEARCH | - |
dc.contributor.googleauthor | Lee, Kyung Hee | - |
dc.contributor.googleauthor | Bae, In Young | - |
dc.contributor.googleauthor | Park, Song I. | - |
dc.contributor.googleauthor | Park, Jong-Dae | - |
dc.contributor.googleauthor | Lee, Hyeon Gyu | - |
dc.relation.code | 2016009954 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF HUMAN ECOLOGY[S] | - |
dc.sector.department | DEPARTMENT OF FOOD & NUTRITION | - |
dc.identifier.pid | hyeonlee | - |
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