Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 은창수 | - |
dc.date.accessioned | 2018-07-31T01:49:52Z | - |
dc.date.available | 2018-07-31T01:49:52Z | - |
dc.date.issued | 2016-07 | - |
dc.identifier.citation | GUT AND LIVER, v. 10, NO 4, Page. 581-586 | en_US |
dc.identifier.issn | 1976-2283 | - |
dc.identifier.issn | 2005-1212 | - |
dc.identifier.uri | http://www.gutnliver.org/journal/view.html?doi=10.5009/gnl15324 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/73800 | - |
dc.description.abstract | Background/Aims: Proton pump inhibitors (PPIs) and histamine-2 receptor antagonists (H2RAs) are commonly prescribed for stress ulcer prophylaxis (SUP) in critically ill patients. Several studies have suggested that the use of PPIs is a potential risk factor for Clostridium difficile infection (CDI). We compared the incidences of CDI in the PPI group and H2RA group for SUP in critically ill patients. Methods: From August 2005 to July 2012, the incidences of CDI were retrospectively analyzed in patients who were admitted directly to intensive care units and stayed for more than 3 days. SUP-related CDI was defined as a CDI diagnosed during the SUP period. Patient clinical data were analyzed to identify potential risk factors for SUP-related CDI. Results: Of the 1,005 patients enrolled (444 patients received PPI and 561 received H2RA), 38 (3.8%) were diagnosed with SUP-related CDI. The incidence of SUP-related CDI was considerably higher in patients who received PPI than in those who received H2RA (6.7% vs 1.8%). PPI use for SUP (odds ratio [OR], 3.3; confidence interval [CI], 1.5 to 7.1; p=0.003) and diabetes mellitus (OR, 2.3; CI, 1.2 to 4.7; p=0.019) were independent risk factors for SUP-related CDI. Conclusions: PPI therapy is associated with a higher risk of SUP-related CDI than H2RA therapy in critically ill patients. | en_US |
dc.description.sponsorship | This work was funded by the research fund of Hanyang University (HY-2013). | en_US |
dc.language.iso | en | en_US |
dc.publisher | EDITORIAL OFFICE GUT & LIVER | en_US |
dc.subject | Clostridium difficile | en_US |
dc.subject | Proton pump inhibitor | en_US |
dc.subject | Histamine-2 receptor antagonist | en_US |
dc.subject | Critical care | en_US |
dc.title | Risk of Clostridium difficile Infection with the Use of a Proton Pump Inhibitor for Stress Ulcer Prophylaxis in Critically Ill Patients | en_US |
dc.type | Article | en_US |
dc.relation.no | 4 | - |
dc.relation.volume | 10 | - |
dc.identifier.doi | 10.5009/gnl15324 | - |
dc.relation.page | 581-586 | - |
dc.relation.journal | GUT AND LIVER | - |
dc.contributor.googleauthor | Ro, Youngouk | - |
dc.contributor.googleauthor | Eun, Chang Soo | - |
dc.contributor.googleauthor | Kim, Hyun Soo | - |
dc.contributor.googleauthor | Kim, Ji Yeoun | - |
dc.contributor.googleauthor | Byun, Young Jae | - |
dc.contributor.googleauthor | Yoo, Kyo-Sang | - |
dc.contributor.googleauthor | Han, Dong Soo | - |
dc.relation.code | 2016005405 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | cseun | - |
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