Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 김영서 | - |
dc.date.accessioned | 2018-07-26T00:56:08Z | - |
dc.date.available | 2018-07-26T00:56:08Z | - |
dc.date.issued | 2012-05 | - |
dc.identifier.citation | European Neurology, 2012, 67(6), P.363-369 | en_US |
dc.identifier.issn | 0014-3022 | - |
dc.identifier.uri | https://www.karger.com/Article/Abstract/335351 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/72999 | - |
dc.description.abstract | Background: Stromal cell-derived factor-1 alpha (SDF-1 alpha) provides neurotrophic support to neurons. In this prospective study, we investigated the association between SDF-1 alpha and long-term outcome in patients with acute ischemic stroke. Methods: This study included 104 patients with first-ever ischemic stroke, identified within 24 h of symptom onset. Serum samples were collected immediately after admission and 3 months thereafter, as well as from age- and sex-matched normal controls. The correlation between acute-stage serum SDF-1 alpha and stroke severity were analyzed. Finally, the relationship between serum SDF-1 alpha and long-term outcome was evaluated by multivariate analysis. Results: Serum SDF-1 alpha levels were only higher in acute-stage stroke patients compared with the normal control group (p = 0.011). The serum SDF-1 alpha level was increased in proportion to infarct volume (r = 0.220, p = 0.025) and initial National Institutes of Health Stroke Scale score (r = 0.275, p = 0.005). After adjustment for covariates, a high initial serum SDF-1 alpha level (OR 1.167, p = 0.023) or second and third tertiles of SDF-1 alpha level compared to first tertile (OR 4.644, p = 0.044 and OR 9.396, p = 0.025, respectively) were significantly associated with a favorable long-term outcome. Conclusions: This prospective study demonstrated a correlation between serum SDF-1 alpha and favorable long-term outcome in patients with acute ischemic stroke. Copyright (C) 2012 S. Karger AG, Basel | en_US |
dc.description.sponsorship | This study was supported by a grant from the Korea Healthcare Technology R&D Project, Ministry for Health and Welfare Affairs, Republic of Korea (A100459, A101712). | en_US |
dc.language.iso | en | en_US |
dc.publisher | KARGER | en_US |
dc.subject | Stromal cell-derived factor-1 alpha | en_US |
dc.subject | Ischemic stroke | en_US |
dc.subject | Stroke outcome | en_US |
dc.subject | Neurotrophic effect | en_US |
dc.title | Association between Serum Stromal Cell-Derived Factor-1 alpha and Long-Term Outcome of Acute Ischemic Stroke | en_US |
dc.type | Article | en_US |
dc.relation.no | 6 | - |
dc.relation.volume | 67 | - |
dc.identifier.doi | 10.1159/000335351 | - |
dc.relation.page | 363-369 | - |
dc.relation.journal | EUROPEAN NEUROLOGY | - |
dc.contributor.googleauthor | Kim, Young Seo | - |
dc.contributor.googleauthor | Baek, Wonki | - |
dc.contributor.googleauthor | Kim, Mi K. | - |
dc.contributor.googleauthor | Kim, Hyun Young | - |
dc.contributor.googleauthor | Lee, Kyu-Yong | - |
dc.contributor.googleauthor | Lee, Young Joo | - |
dc.contributor.googleauthor | Kim, Seung Hyun | - |
dc.contributor.googleauthor | Chang, Dae-Il | - |
dc.contributor.googleauthor | Koh, Seong-Ho | - |
dc.relation.code | 2012203072 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | kimys1 | - |
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