Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Akash Deep | - |
dc.date.accessioned | 2018-07-06T05:16:14Z | - |
dc.date.available | 2018-07-06T05:16:14Z | - |
dc.date.issued | 2016-06 | - |
dc.identifier.citation | ACS APPLIED MATERIALS & INTERFACES, v.8, no.26, Page. 16555-16563 | en_US |
dc.identifier.issn | 1944-8244 | - |
dc.identifier.uri | https://pubs.acs.org/doi/10.1021/acsami.6b03079 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/72408 | - |
dc.description.abstract | We report an efficient method for the synthesis of few-layered MoS2 nanosheets and demonstrate their application in the label-free detection of the prostate-specific antigen (PSA) cancer marker. As a novel strategy, the electro-dissolution of molybdenum metal sheets in the presence of Na+ and S2- ions led to the formation of Na+ intercalated MoS2. Further exfoliation by ultrasonication yielded the desired formation of few-layered MoS2 nanosheets. After comprehensive characterization, the synthesized MoS2 nanosheets were channeled in a field-effect transistor (FET) microdevice. Chemically reduced anti-PSA antibodies were immobilized on the MoS2 channel above the FET microdevice to construct a specific PSA immunosensor. The antibodies were deliberately reduced to expose the hinge-region disulfide bonds. This approach offered a robust and site-directed immunosensing device through biointerfacing of the sulfhydryl groups (SH) in the reduced antibody with the surface S atoms of MoS2. This device was validated as an effective immunosensor with a low detection limit (10(-5)ng/mL) over a wide linear detection range (10(-5) to 75 ng/mL). | en_US |
dc.description.sponsorship | Financial support from the CSIR project OMEGA/PSC0202 is gratefully acknowledged. M.K. and S.K.T. thank CSIR, India for their research fellowships. We are also grateful to the Directors of the CSIR-CSIO, Chandigarh and INST, Mohali. K.H.K. also acknowledges support made by a National Research Foundation of Korea (NRF) grant funded by the Ministry of Education, Science, and Technology (MEST) (No. 2009-0093848). We are also thankful to Dr. Ajay Agarwal of CSIR-CEERI, Pilani Dr. Vinod of INST, Mohali for the samples of FET chips and SEM analysis, respectively. The help from the Public Computerized Laboratory, Fatehgarh, Punjab (India) is acknowledged for providing human serum samples. | en_US |
dc.language.iso | en | en_US |
dc.publisher | AMER CHEMICAL SOC | en_US |
dc.subject | few-layered nanosheets | en_US |
dc.subject | MoS2 | en_US |
dc.subject | reduced antibody | en_US |
dc.subject | immunosensor | en_US |
dc.subject | prostate-specific antigen | en_US |
dc.subject | FET | en_US |
dc.title | A new electrolytic synthesis method for few-layered MoS2 nanosheets and their robust biointerfacing with reduced antibodies. | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.1021/acsami.6b03079 | - |
dc.relation.page | 1-9 | - |
dc.relation.journal | ACS APPLIED MATERIALS & INTERFACES | - |
dc.contributor.googleauthor | Kukkar, Manil | - |
dc.contributor.googleauthor | Tuteja, Satish K. | - |
dc.contributor.googleauthor | Sharma, Amit L. | - |
dc.contributor.googleauthor | Kumar, Vinod | - |
dc.contributor.googleauthor | Paul, Ashok K. | - |
dc.contributor.googleauthor | Kim, Ki-Hyun | - |
dc.contributor.googleauthor | Sabherwal, Priyanka | - |
dc.contributor.googleauthor | Deep, Akash | - |
dc.relation.code | 2016001740 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF ENGINEERING[S] | - |
dc.sector.department | DEPARTMENT OF CIVIL AND ENVIRONMENTAL ENGINEERING | - |
dc.identifier.pid | akashdeep | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.