Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김태형 | - |
dc.date.accessioned | 2018-04-30T02:20:11Z | - |
dc.date.available | 2018-04-30T02:20:11Z | - |
dc.date.issued | 2016-05 | - |
dc.identifier.citation | RESPIRATION, v. 91, NO 5, Page. 351-358 | en_US |
dc.identifier.issn | 0025-7931 | - |
dc.identifier.issn | 1423-0356 | - |
dc.identifier.uri | https://www.karger.com/Article/FullText/445266 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/71034 | - |
dc.description.abstract | Background: Vitamin D is suggested to play a role in airway and systemic inflammation in chronic obstructive pulmonary disease (COPD). Low serum 25-hydroxyvitamin D (25-OHD) levels have been suggested to be associated with lower lung function and poorer exercise capacity in COPD. Objectives: The main purpose of this study was to investigate the effects of vitamin D deficiency on the change in exercise capacity in male COPD patients. Methods: A total of 156 male subjects were selected from the Korean Obstructive Lung Disease cohort. Vitamin D deficiency was subdivided into three subgroups: mild, moderate, and severe deficiency groups. Rapid decline was defined as an annual rate of change in exercise capacity ˃= 17 m. Exercise capacity was assessed by 6-minute walk distance (6MWD). Results: Significant differences were observed in the serum levels of 25-OHD, the number of patients with vitamin D sufficiency, and moderate-to-severe deficiency between rapid decliners (n = 40) and non-rapid decliners (n = 116). No differences were found between the groups for age, smoking status, lung function, and 6MWD. Multivariate analysis showed that vitamin D deficiency was independently related to rapid decline in exercise capacity (p = 0.028). A statistically significant difference was observed among the subgroups of vitamin D deficiency in terms of the change in exercise capacity (p ˂ 0.001). The annual decline in exercise capacity was prominent in the severe deficiency group (23.1 m/year). Conclusion: This study shows that vitamin D deficiency is associated with rapid decline in exercise capacity in male patients with COPD. (C) 2016 S. Karger AG, Basel | en_US |
dc.description.sponsorship | This study was supported by a grant from the Korea Healthcare Technology R & D Project, Ministry of Health & Welfare, Republic of Korea (A102065). This research was supported by Hallym University Research Fund 2014 (HURF-20140104). | en_US |
dc.language.iso | en | en_US |
dc.publisher | KARGER | en_US |
dc.subject | Chronic obstructive pulmonary disease | en_US |
dc.subject | Vitamin D deficiency | en_US |
dc.subject | Exercise capacity | en_US |
dc.subject | Six-minute walk distance | en_US |
dc.title | Vitamin D Deficiency Is Associated with Rapid Decline in Exercise Capacity in Male Patients with Chronic Obstructive Pulmonary Disease | en_US |
dc.type | Article | en_US |
dc.relation.no | 5 | - |
dc.relation.volume | 91 | - |
dc.identifier.doi | 10.1159/000445266 | - |
dc.relation.page | 351-358 | - |
dc.relation.journal | RESPIRATION | - |
dc.contributor.googleauthor | Kim, Changhwan | - |
dc.contributor.googleauthor | Jung, Ji Ye | - |
dc.contributor.googleauthor | Kim, Young Sam | - |
dc.contributor.googleauthor | Lee, Jae Seung | - |
dc.contributor.googleauthor | Rhee, Chin Kook | - |
dc.contributor.googleauthor | Lee, Jin Hwa | - |
dc.contributor.googleauthor | Lee, Ji-Hyun | - |
dc.contributor.googleauthor | Kim, Tae-Hyung | - |
dc.contributor.googleauthor | Lim, Seong Yong | - |
dc.contributor.googleauthor | Sheen, Seung Soo | - |
dc.relation.code | 2016002786 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | drterry | - |
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