Association between Symptoms of Irritable Bowel Syndrome and Methane and Hydrogen on Lactulose Breath Test

Title
Association between Symptoms of Irritable Bowel Syndrome and Methane and Hydrogen on Lactulose Breath Test
Author
최호순
Keywords
Irritable Bowel Syndrome; Lactulose Breath Test; Intestinal Gas; Hydrogen; Methane
Issue Date
2013-06
Publisher
대한의학회
Citation
J Korean Med Sci, 28, 6, 901-907
Abstract
Whether hydrogen and methane gas produced during lactulose breath test (LBT) are associated with symptoms of irritable bowel syndrome (IBS) is not determined. We aimed to investigate whether hydrogen and methane on LBT are associated with IBS symptoms.Sixty-eight IBS patients meeting the Rome III criteria for IBS, and 55 healthy controls,underwent LBT. The IBS subjects recorded their customary gastrointestinal symptoms on a questionnaire using visual analogue scales. LBT positivity was defined to be above 20 ppm rise of hydrogen or 10 ppm rise of methane within 90 min. Gas amounts produced during LBT were determined by calculating area under the curve of hydrogen and methane excretion. Symptom severity scores were not different between the LBT (+) IBS and LBT (-)IBS subjects and also between methane producers and non-methane producers. Gas amounts produced during LBT were not associated with IBS symptoms, except a weak correlation between total gas amounts and a few IBS symptoms such as bloating (r = 0.324, P = 0.039), flatulence (r = 0.314, P = 0.046) and abdominal pain (r = 0.364,P = 0.018) only in LBT (+) IBS. In conclusion, hydrogen and methane gas on LBT are not useful for predicting the customary symptoms and subtypes of IBS.
URI
https://synapse.koreamed.org/DOIx.php?id=10.3346/jkms.2013.28.6.901http://repository.hanyang.ac.kr/handle/20.500.11754/70729
ISSN
1011-8934; 1598-6357
DOI
10.3346/jkms.2013.28.6.901
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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