Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 최호진 | - |
dc.date.accessioned | 2018-04-19T11:49:26Z | - |
dc.date.available | 2018-04-19T11:49:26Z | - |
dc.date.issued | 2013-01 | - |
dc.identifier.citation | BIOMOLECULES & THERAPEUTICS | en_US |
dc.identifier.issn | 1976-9148 | - |
dc.identifier.issn | 2005-4483 | - |
dc.identifier.uri | http://koreascience.or.kr/article/ArticleFullRecord.jsp?cn=OOOMB4_2013_v21n1_72 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/69817 | - |
dc.description.abstract | This work aimed to assess some pharmacological activities of P. leptostachya var. asiatica Hara. The dried roots of P. leptostachya var. asiatica Hara were extracted with 70% ethanol to generate the powdered extract, named PLE. Anti-angiogenic activity was detected using chick chorioallantoic membrane (CAM) assay. In vitro anti-inflammatory activity was evaluated via analyzing nitric oxide (NO) content, inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophage cells. Antioxidant activity was determined by 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay and reactive oxygen species (ROS) level in the stimulated macrophage cells. Matrix metalloproteinase-9 (MMP-9) and -2 (MMP-2) activities in the culture media were detected using zymography. PLE exhibits an anti-angiogenic activity in the CAM assay, and displays an inhibitory action on the generation of NO in the LPS-stimulated macrophage cells. In the stimulated macrophage cells, it is able to diminish the enhanced ROS level. It can potently scavenge the stable DPPH free radical. It suppresses the induction of iNOS and COX-2 and the enhanced MMP-9 activity in the stimulated macrophage cells. Both monooxygenase and oxidase activities of tyrosinase were strongly inhibited by PLE. Taken together, the dried roots of P. leptostachya var. asiatica Hara possess anti-angiogenic, anti-inflammatory, antioxidant and skin whitening activities, which might partly provide its therapeutic efficacy in traditional medicine. | en_US |
dc.description.sponsorship | This study was supported by a grant of the Korea Healthcare Technology R&D Project, Ministry of Health & Welfare, Republic of Korea (Grant No. : A103017). This study was supported in part by Kangwon National University. The authors are grateful to Ms A Rum Park and Ms Yu-Mi Shin for their technical assistances. | en_US |
dc.language.iso | en | en_US |
dc.publisher | KOREAN SOC APPLIED PHARMACOLOGY | en_US |
dc.subject | Anti-angiogenic | en_US |
dc.subject | Anti-inflammatory | en_US |
dc.subject | Antioxidant | en_US |
dc.subject | Matrix metalloproteinase-9 | en_US |
dc.subject | Skin whitening | en_US |
dc.subject | Phryma leptostachya var | en_US |
dc.subject | asiatica Hara | en_US |
dc.title | Anti-Inflammatory, Antioxidant, Anti-Angiogenic and Skin Whitening Activities of Phryma leptostachya var. asiatica Hara Extract | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.4062/biomolther.2012.059 | - |
dc.relation.journal | BIOMOLECULES & THERAPEUTICS | - |
dc.contributor.googleauthor | Jung, HJ | - |
dc.contributor.googleauthor | Cho, YW | - |
dc.contributor.googleauthor | Lim, HW | - |
dc.contributor.googleauthor | Chol, H | - |
dc.contributor.googleauthor | Ji, DJ | - |
dc.contributor.googleauthor | Lim, CJ | - |
dc.relation.code | 2013001211 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | chj | - |
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