Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 박준성 | - |
dc.date.accessioned | 2018-04-19T11:47:07Z | - |
dc.date.available | 2018-04-19T11:47:07Z | - |
dc.date.issued | 2013-01 | - |
dc.identifier.citation | Pharmacology, 2013, 91(1-2), P.20-28 | en_US |
dc.identifier.issn | 0031-7012 | - |
dc.identifier.uri | https://www.karger.com/Article/Abstract/343764 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/69813 | - |
dc.description.abstract | This study was undertaken to determine if mycophenolic acid (MPA) inhibits the profibrotic action of cyclosporin A (CsA) and, if so, to determine the molecular mechanisms involved. The effect of MPA treatment on CsA-induced signaling through the transforming growth factor-beta (TGF-beta)/Smad pathway was evaluated by immunoblot analysis in cultured primary rat mesangial cells. Treatment of cells with 1 mu mol/l MPA did not significantly decrease the CsA-induced expression of TGF-beta(1), but partially reversed the increases in Smad3 phosphorylation and fibronectin (FBN) production, and increased Smad7 expression. These results suggest that MPA may ameliorate CsA-induced FBN production by modulating the Smad signaling pathway. This study provides evidence that MPA can attenuate CsA-induced renal injury after kidney transplantation. copyright (C) 2012 S. Karger AG, Basel | en_US |
dc.language.iso | en | en_US |
dc.publisher | S. Karger AG | en_US |
dc.subject | Cyclosporin | en_US |
dc.subject | Fibrosis | en_US |
dc.subject | Transforming growth factor-beta | en_US |
dc.subject | Smad proteins | en_US |
dc.title | Effect of Mycophenolic Acid on Cyclosporin A-Induced Fibronectin Expression in Rat Mesangial Cells | en_US |
dc.type | Article | en_US |
dc.relation.no | 1-2 | - |
dc.relation.volume | 91 | - |
dc.identifier.doi | 10.1159/000343764 | - |
dc.relation.page | 20-28 | - |
dc.relation.journal | PHARMACOLOGY | - |
dc.contributor.googleauthor | Park, J. S. | - |
dc.contributor.googleauthor | Kim, G. H. | - |
dc.contributor.googleauthor | Jo, C. H. | - |
dc.contributor.googleauthor | Kim, S. | - |
dc.contributor.googleauthor | Lee, C. H. | - |
dc.contributor.googleauthor | Kim, Y. S. | - |
dc.contributor.googleauthor | Kang, C. M. | - |
dc.relation.code | 2013011649 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | sjpjoon | - |
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