Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김원규 | - |
dc.date.accessioned | 2018-04-19T07:10:48Z | - |
dc.date.available | 2018-04-19T07:10:48Z | - |
dc.date.issued | 2012-10 | - |
dc.identifier.citation | CLINICAL AND EXPERIMENTAL IMMUNOLOGY, OCT 2012, 170(1), p66-p76, 11p. | en_US |
dc.identifier.issn | 0009-9104 | - |
dc.identifier.uri | https://onlinelibrary.wiley.com/doi/full/10.1111/j.1365-2249.2012.04637.x | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/69450 | - |
dc.description.abstract | Forkhead box protein 3 (FoxP3+) regulatory T (Treg) cells and interleukin (IL)-17-producing T helper 17 (Th17) cells have opposing effects on autoimmunity, as the former are crucial for maintaining self-tolerance while the latter play a key role in precipitating inflammatory autoimmune diseases. Here we report that Bacillus-derived poly-?-glutamic acid (?-PGA) signals naive CD4+ T cells to promote the selective differentiation of Treg cells and to suppress the differentiation of Th17 cells. The ?-PGA inducibility of FoxP3 expression was due partially to transforming growth factor (TGF)-beta induction through a Toll-like receptor (TLR)-4/myeloid differentiating factor 88 (MyD88)-dependent pathway. However, this pathway was dispensable for ?-PGA suppression of Th17 differentiation. ?-PGA inhibited IL-6-driven induction of Th17-specific factors including signal transducer and activator of transcription-3 (STAT-3) and retinoic acid-related orphan receptor ?t (ROR?t) while up-regulating the STAT-3 inhibitor suppressor of cytokine signalling 3 (SOCS3). Importantly, in vivo administration of ?-PGA attenuated the symptoms of experimental autoimmune encephalomyelitis and at the same time reduced Th17 cell infiltrates in the central nervous system. Thus, we have identified the microbe-associated molecular pattern, ?-PGA, as a novel regulator of autoimmune responses, capable of promoting the differentiation of anti-inflammatory Treg cells and suppressing the differentiation of proinflammatory Th17 cells. These findings draw attention to the potential of ?-PGA for treating Th17 cell-mediated autoimmune diseases. | en_US |
dc.description.sponsorship | We thank Drs Shizuo Akira and Myung-Shik Lee forproviding MyD88-/-mice, Ms Eun-Hyun Kim for technicalassistance and Dr Julian Gross for editorial assistance. Thiswork was supported by a National Research Foundationgrant funded by the Korean government (MEST; 2009-0081790). | en_US |
dc.language.iso | en | en_US |
dc.publisher | WILEY-BLACKWELL, 111 RIVER ST, HOBOKEN 07030-5774, NJ USA | en_US |
dc.subject | autoimmune disease | en_US |
dc.subject | experimental autoimmune encephalomyelitis | en_US |
dc.subject | poly-?-glutamic acid | en_US |
dc.subject | regulatory T cells | en_US |
dc.subject | Th17 cells | en_US |
dc.subject | TRANSCRIPTION FACTOR FOXP3 | en_US |
dc.subject | MULTIPLE-SCLEROSIS | en_US |
dc.subject | SCURFY MOUSE | en_US |
dc.subject | PATHWAYS | en_US |
dc.subject | T(H)17 | en_US |
dc.subject | BETA | en_US |
dc.subject | GENERATION | en_US |
dc.subject | EXPRESSION | en_US |
dc.subject | INFLAMMATION | en_US |
dc.subject | INDUCTION | en_US |
dc.title | Bacillus-derived poly-gamma-glutamic acid reciprocally regulates the differentiation of T helper 17 and regulatory T cells and attenuates experimental autoimmune encephalomyelitis | en_US |
dc.type | Article | en_US |
dc.relation.no | 1 | - |
dc.relation.volume | 170 | - |
dc.identifier.doi | 10.1111/j.1365-2249.2012.04637.x | - |
dc.relation.page | 66-76 | - |
dc.relation.journal | CLINICAL AND EXPERIMENTAL IMMUNOLOGY | - |
dc.contributor.googleauthor | Lee, K. | - |
dc.contributor.googleauthor | Hwang, S. | - |
dc.contributor.googleauthor | Paik, D. J. | - |
dc.contributor.googleauthor | Kim, W. K. | - |
dc.contributor.googleauthor | Youn, J. | - |
dc.contributor.googleauthor | Kim, J. M. | - |
dc.relation.code | 2012201973 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | kimwg | - |
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