PAN hollow fiber membranes elicit functional hippocampal neuronal network
- Title
- PAN hollow fiber membranes elicit functional hippocampal neuronal network
- Author
- Enrico Drioli
- Keywords
- Hippocampal Neuron Brain; Derive Neurotrophic Factor; Neuronal Network; Neurobasal Medium; Recede Contact Angle
- Issue Date
- 2012-01
- Publisher
- Springer Science + Business Media
- Citation
- Journal of Materials Science: Materials in Medicine, Vol.23, No.1 [2012], p149–156
- Abstract
- This study focuses on the development of an advanced in vitro biohybrid culture model system based on the use of hollow fibre membranes (HFMs) and hippocampal neurons in order to promote the formation of a high density neuronal network. Polyacrylonitrile (PAN) and modified polyetheretherketone (PEEK-WC) membranes were prepared in hollow fibre configuration. The morphological and metabolic behaviour of hippocampal neurons cultured on PAN HF membranes were compared with those cultured on PEEK-WC HF. The differences of cell behaviour between HFMs were evidenced by the morphometric analysis in terms of axon length and also by the investigation of metabolic activity in terms of neurotrophin secretion. These findings suggested that PAN HFMs induced the in vitro reconstruction of very highly functional and complex neuronal networks. Thus, these biomaterials could potentially be used for the in vitro realization of a functional hippocampal tissue analogue for the study of neurobiological functions and/or neurodegenerative diseases.
- URI
- http://link.springer.com/article/10.1007/s10856-011-4484-3http://hdl.handle.net/20.500.11754/67812
- ISSN
- 0957-4530
- DOI
- 10.1007/s10856-011-4484-3
- Appears in Collections:
- COLLEGE OF ENGINEERING[S](공과대학) > ENERGY ENGINEERING(에너지공학과) > Articles
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