Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김상헌 | - |
dc.date.accessioned | 2018-04-15T14:10:14Z | - |
dc.date.available | 2018-04-15T14:10:14Z | - |
dc.date.issued | 2012-05 | - |
dc.identifier.citation | ALLERGY ASTHMA & IMMUNOLOGY RESEARCH, Vol.4, No.3 [2012], p132-p136 | en_US |
dc.identifier.issn | 2092-7355 | - |
dc.identifier.uri | https://synapse.koreamed.org/DOIx.php?id=10.4168/aair.2012.4.3.132 | - |
dc.description.abstract | Purpose: Drug-induced liver injury (DILI) is the most common adverse drug reaction; however, it is not easily predicted. We hypothesize that DILI has a common genetic basis. Based on the findings of previous animal studies on toxic hepatitis, we selected the thioredoxin reductase 1 gene (TXNRD1) as a candidate marker of DILI for this genetic association study. Methods: Records from 118 patients with DILI were extracted from the database of the Adverse Drug Reaction Research Group in South Korea. Causative drugs included antituberculosis drugs (n=68, 57.6%), antibiotics (n=22, 18.6%), antiepileptic drugs (n=7, 5.9%), non-steroidal anti-inflammatory drugs (n=5, 4.2%), and others (n=16, 13.7%). Seven single nucleotide polymorphisms (SNPs) in TXNRD1 (rs10735393, rs4964287, rs4595619, rs10861201, rs11111997, rs4246270, and rs4246271) were scored in 118 DILI patients and in 120 drug-matched controls without liver injury. Results: No differences were found between the frequencies of any of the 7 SNPs in the cases and controls; however, a significant association was found between a TTA haplotype composed of rs10735393, rs4964287, and rs4595619 and DILI using an allele model (odds ratio, 1.79; 95% confidence interval, 1.18-2.73; P=0.008; Bonferroni corrected P=0.024). Conclusions:These results suggest that genetic variations in TXNRD1 favor the development of DILI, although a larger confirmative study is needed. | en_US |
dc.description.sponsorship | This work was supported by a grant from the Korea Health 21 R&D Project (A111218-11-PG01) from the Ministry of Health and Welfare, Republic of Korea. | en_US |
dc.language.iso | en | en_US |
dc.publisher | 대한천식알레르기학회 | en_US |
dc.subject | Drug-induced liver injury | en_US |
dc.subject | genetic association study | en_US |
dc.subject | genetic polymorphism | en_US |
dc.subject | single nucleotide polymorphisms | en_US |
dc.subject | thioredoxin reductase 1 | en_US |
dc.title | Genetic Variations in TXNRD1 as Potential Predictors of Drug-Induced Liver Injury | en_US |
dc.type | Article | en_US |
dc.relation.no | 3 | - |
dc.relation.volume | 4 | - |
dc.identifier.doi | 10.4168/aair.2012.4.3.132 | - |
dc.relation.page | 132-136 | - |
dc.relation.journal | ALLERGY ASTHMA & IMMUNOLOGY RESEARCH | - |
dc.contributor.googleauthor | Kwon, Jae-Woo | - |
dc.contributor.googleauthor | Shin, Eun-Soon | - |
dc.contributor.googleauthor | Lee, Jong-Eun | - |
dc.contributor.googleauthor | Kim, Sang-Heon | - |
dc.contributor.googleauthor | Kim, Sang-Hoon | - |
dc.contributor.googleauthor | Jee, Young-Koo | - |
dc.contributor.googleauthor | Kim, Yoon-Keun | - |
dc.contributor.googleauthor | Park, Hae-Sim | - |
dc.contributor.googleauthor | Min, Kyung-Up | - |
dc.contributor.googleauthor | Park, Heung-Woo | - |
dc.relation.code | 2012247444 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | sangheonkim | - |
dc.identifier.researcherID | 57016220900 | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.