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알코올의존의 Lesch의 유형학에 따른 신경생물학적 특성 및 임상적 특성

Title
알코올의존의 Lesch의 유형학에 따른 신경생물학적 특성 및 임상적 특성
Other Titles
Neurobiological and Clinical Characteristics According to Lesch's Typology in Alcohol Dependence
Author
채영규
Keywords
알코올의존장애; Lesch 유형학; 신경생물학적 소견; 치료 반응; Alcohol dependence; Lesch's typology; Neurobiological finding; Treatment responsen
Issue Date
2011-08
Publisher
대한생물정신의학회
Citation
생물정신의학, 2011, 18(3), P.109-118
Abstract
Objectives Many studies have suggested different neurobiological findings and clinical courses in alcoholism. Recently, subtyping in alcohol dependence has become essential to overcome the heterogeneity of patients. Among several criteria of subtypes, Lesch's typology is proposed to integrate biological, social, and psychological factors. This review provides neurobiological findings and treatment-responses of alcohol dependence according to Lesch's typology. Method We searched the international published medical literature using the search terms 'Lesch's typology' and 'alcohol dependence' and using the limits 'human'. Results We identified 17 studies with subjects of alcohol dependence according to Lesch's typology. Conclusion They indicated that each subtype of Lesch's typology can have specific neurobiological factors and different clinical responses as follows. Lesch's subtype 1 is characterized by severe withdrawal symptoms and associated with elevated glutamate and homocysteine. Lesch's subtype 2 is defined by individuals who drink alcohol as self-medication for anxiety. Their craving has significant positive correlations with prolactin, leptin level, or intake-volume (vasopressin). Lesch's subtype 4 is related to cerebral dysfunction and associated with increased glutamate and left-handedness. Clinical trials showed that naltrexone was effective in Lesch's subtype 3 and 4 patients, while acamprosate was effective in the subtypes 1 and 2.
URI
http://www.ndsl.kr/ndsl/search/detail/article/articleSearchResultDetail.do?cn=JAKO201129665546425&SITE=CLICK
ISSN
1225-8709; 2005-7571
Appears in Collections:
GRADUATE SCHOOL[S](대학원) > BIONANOTECHNOLOGY(바이오나노학과) > Articles
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