Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 채영규 | - |
dc.date.accessioned | 2018-04-15T13:16:46Z | - |
dc.date.available | 2018-04-15T13:16:46Z | - |
dc.date.issued | 2011-08 | - |
dc.identifier.citation | 생물정신의학, 2011, 18(3), P.109-118 | en_US |
dc.identifier.issn | 1225-8709 | - |
dc.identifier.issn | 2005-7571 | - |
dc.identifier.uri | http://www.ndsl.kr/ndsl/search/detail/article/articleSearchResultDetail.do?cn=JAKO201129665546425&SITE=CLICK | - |
dc.description.abstract | Objectives Many studies have suggested different neurobiological findings and clinical courses in alcoholism. Recently, subtyping in alcohol dependence has become essential to overcome the heterogeneity of patients. Among several criteria of subtypes, Lesch's typology is proposed to integrate biological, social, and psychological factors. This review provides neurobiological findings and treatment-responses of alcohol dependence according to Lesch's typology. Method We searched the international published medical literature using the search terms 'Lesch's typology' and 'alcohol dependence' and using the limits 'human'. Results We identified 17 studies with subjects of alcohol dependence according to Lesch's typology. Conclusion They indicated that each subtype of Lesch's typology can have specific neurobiological factors and different clinical responses as follows. Lesch's subtype 1 is characterized by severe withdrawal symptoms and associated with elevated glutamate and homocysteine. Lesch's subtype 2 is defined by individuals who drink alcohol as self-medication for anxiety. Their craving has significant positive correlations with prolactin, leptin level, or intake-volume (vasopressin). Lesch's subtype 4 is related to cerebral dysfunction and associated with increased glutamate and left-handedness. Clinical trials showed that naltrexone was effective in Lesch's subtype 3 and 4 patients, while acamprosate was effective in the subtypes 1 and 2. | en_US |
dc.language.iso | ko_KR | en_US |
dc.publisher | 대한생물정신의학회 | en_US |
dc.subject | 알코올의존장애 | en_US |
dc.subject | Lesch 유형학 | en_US |
dc.subject | 신경생물학적 소견 | en_US |
dc.subject | 치료 반응 | en_US |
dc.subject | Alcohol dependence | en_US |
dc.subject | Lesch's typology | en_US |
dc.subject | Neurobiological finding | en_US |
dc.subject | Treatment responsen | en_US |
dc.title | 알코올의존의 Lesch의 유형학에 따른 신경생물학적 특성 및 임상적 특성 | en_US |
dc.title.alternative | Neurobiological and Clinical Characteristics According to Lesch's Typology in Alcohol Dependence | en_US |
dc.type | Article | en_US |
dc.relation.no | 3 | - |
dc.relation.volume | 18 | - |
dc.relation.page | 109-118 | - |
dc.relation.journal | 생물정신의학 | - |
dc.contributor.googleauthor | 최미란 | - |
dc.contributor.googleauthor | 채영규 | - |
dc.contributor.googleauthor | 이분희 | - |
dc.contributor.googleauthor | 이준석 | - |
dc.contributor.googleauthor | Choi, Mi-Ran | - |
dc.contributor.googleauthor | Choi, Young-Gyu | - |
dc.contributor.googleauthor | Lee, Bun-Hee | - |
dc.contributor.googleauthor | Lee, Jun-Seok | - |
dc.relation.code | 2012216390 | - |
dc.sector.campus | S | - |
dc.sector.daehak | GRADUATE SCHOOL[S] | - |
dc.sector.department | DEPARTMENT OF BIONANOTECHNOLOGY | - |
dc.identifier.pid | ygchai | - |
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