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XRCC1 Polymorphisms and Risk of Papillary Thyroid Carcinoma in a Korean Sample

Title
XRCC1 Polymorphisms and Risk of Papillary Thyroid Carcinoma in a Korean Sample
Author
조석현
Keywords
Polymorphisms; XRCC1; SNP; Papillary Thyroid Carcinoma; Susceptibility
Issue Date
2011-08
Publisher
Korean ACAD Medical Science
Citation
Journal of Korean Medical Science, 2011, 26(8), P.991-995
Abstract
Polymorphisms of DNA repair genes, X-ray repair cross-complementing group 1 (XRCC1) might contribute to individual susceptibility to different types of cancers. We analyzed the relationship between XRCC1 polymorphisms and the risk of papillary thyroid carcinoma in a Korean sample. A hospital-based case-control study was performed in 111 papillary thyroid carcinoma patients and 100 normal control subjects. XRCC1 Arg194Trp and Arg399Gln single nucleotide polymorphisms (SNPs) were genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). The XRCC1 Arg194Trp Arg/Trp genotype was significantly associated with a decreased risk of papillary thyroid carcinoma compared to that of Arg/Arg genotype (odds ratio [95% confidence intervals]; 0.550 [0.308-0.9831). There was no significant association between XRCC1 Arg399Gln genotypes and risk of papillary thyroid carcinoma. Based on these results, the XRCC1 Arg194Trp Arg/Trp genotype could be used as a useful molecular biomarker to predict genetic susceptibility for papillary thyroid carcinoma in Koreans.
URI
https://synapse.koreamed.org/DOIx.php?id=10.3346/jkms.2011.26.8.991
ISSN
1011-8934; 1598-6357
DOI
10.3346/jkms.2011.26.8.991
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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