An HR-MAS MR Metabolomics Study on Breast Tissues Obtained with Core Needle Biopsy
- Title
- An HR-MAS MR Metabolomics Study on Breast Tissues Obtained with Core Needle Biopsy
- Author
- 구혜령
- Keywords
- Adult; Aged; Biopsy; Needle; methods; Breast; cytology; metabolism; pathology; Breast Neoplasms; diagnosis; Discriminant Analysis; Female; Humans; Magnetic Resonance Spectroscopy
- Issue Date
- 2011-06
- Publisher
- Medline
- Citation
- PLOS ONE, 2011, 6(10)
- Abstract
- BackgroundMuch research has been devoted to the development of new breast cancer diagnostic measures, including those involving high-resolution magic angle spinning (HR-MAS) magnetic resonance (MR) spectroscopic techniques. Previous HR-MAS MR results have been obtained from post-surgery samples, which limits their direct clinical applicability.Methodology/Principal FindingsIn the present study, we performed HR-MAS MR spectroscopic studies on 31 breast tissue samples (13 cancer and 18 non-cancer) obtained by percutaneous core needle biopsy. We showed that cancer and non-cancer samples can be discriminated very well with Orthogonal Projections to Latent Structure-Discriminant Analysis (OPLS-DA) multivariate model on the MR spectra. A subsequent blind test showed 69% sensitivity and 94% specificity in the prediction of the cancer status. A spectral analysis showed that in cancer cells, taurine- and choline-containing compounds are elevated. Our approach, additionally, could predict the progesterone receptor statuses of the cancer patients.Conclusions/SignificanceHR-MAS MR metabolomics on intact breast tissues obtained by core needle biopsy may have a potential to be used as a complement to the current diagnostic and prognostic measures for breast cancers.
- URI
- http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0025563http://hdl.handle.net/20.500.11754/66714
- ISSN
- 1932-6203
- DOI
- 10.1371/journal.pone.0025563
- Appears in Collections:
- COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
- Files in This Item:
- An HR-MAS MR Metabolomics Study on Breast Tissues Obtained with Core Needle Biopsy.PDFDownload
- Export
- RIS (EndNote)
- XLS (Excel)
- XML