Enhanced performance of a tandem simulated moving bed process for separation of paclitaxel, 13-dehydroxybaccatin III, and 10-deacetylpaclitaxel by making a difference between the adsorbent particle sizes of the two subordinate simulated moving bed units
- Title
- Enhanced performance of a tandem simulated moving bed process for separation of paclitaxel, 13-dehydroxybaccatin III, and 10-deacetylpaclitaxel by making a difference between the adsorbent particle sizes of the two subordinate simulated moving bed units
- Author
- 문성용
- Keywords
- Tandem simulated moving bed; Paclitaxel separation; Standing wave design; Productivity; Adsorbent particle size; Process optimization
- Issue Date
- 2011-06
- Publisher
- Elsevier Science B.V., Amsterdam.
- Citation
- Process biochemistry, 2011, 46(6), pp.1329 - 1334
- Abstract
- A tandem simulated moving bed (SMB) process, which consists of two four-zone SMB units (Ring I and Ring II) in series, has been developed previously for complete separation of a ternary bioproduct mixture. In all of previous studies on the optimization of such a tandem SMB process, the adsorbent particle sizes in Ring I and Ring II have been kept the same. To make a further improvement in the performance of a tandem SMB, one can adopt the strategy of making a difference between the adsorbent particle sizes of Ring I and Ring II, which was studied in this paper using the ternary paclitaxel-related mixture as an example separation system. The results showed that the proposed strategy led the adsorbent particle sizes in Ring I and Ring II to be selected in favor of reducing the product dilution of Ring I and reducing the pressure drop of Ring II, respectively. Such pattern of particle-size selection resulted in a marked improvement in the productivity of the tandem SMB of interest, which was confirmed for both the low-pressure and the high-pressure systems. Furthermore, such advantage of the proposed strategy became more pronounced as the selectivity related to the ternary separation was reduced. (C) 2011 Elsevier Ltd. All rights reserved.
- URI
- https://www.sciencedirect.com/science/article/pii/S1359511311000961http://hdl.handle.net/20.500.11754/66576
- ISSN
- 1359-5113
- DOI
- 10.1016/j.procbio.2011.02.026
- Appears in Collections:
- COLLEGE OF ENGINEERING[S](공과대학) > CHEMICAL ENGINEERING(화학공학과) > Articles
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