Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 구혜령 | - |
dc.date.accessioned | 2018-04-15T02:11:53Z | - |
dc.date.available | 2018-04-15T02:11:53Z | - |
dc.date.issued | 2012-07 | - |
dc.identifier.citation | JOURNAL OF MAGNETIC RESONANCE IMAGING, 2012, 36(1), P.145-151 | en_US |
dc.identifier.issn | 1053-1807 | - |
dc.identifier.uri | https://onlinelibrary.wiley.com/doi/abs/10.1002/jmri.23635 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/66391 | - |
dc.description.abstract | PURPOSE:To investigate whether a correlation exists between perfusion parameters obtained from dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) and prognostic factors or immunohistochemical subtypes of breast cancers.MATERIALS AND METHODS:Quantitative parameters (K(trans) , k(ep) , and v(e) ) of 70 invasive ductal carcinomas were obtained using DCE-MRI as a postprocessing procedure. Correlations between parameters and prognostic factors, including tumor size, axillary nodal status, histologic grade, nuclear grade, expression of estrogen receptor (ER), progesterone receptor (PR), Ki-67, p53, bcl-2, and human epidermal growth factor receptor 2 (HER2) and subtypes categorized as luminal (ER or PR-positive), triple negative (ER or PR-negative, HER2-negative), and HER2 (ER and PR-negative, HER2 overexpression) were analyzed.RESULTS:Mean K(trans) was higher in tumors with a high histologic grade than with a low histologic grade (P = 0.007), with a high nuclear grade than with a low nuclear grade (P = 0.002), and with ER negativity than ER positivity (P = 0.056). Mean k(ep) was higher in tumors with a high histologic grade than with a low histologic grade (P = 0.005), with a high nuclear grade than with a low nuclear grade (P = 0.001), and with ER negativity than with ER positivity (P = 0.043). Mean v(e) was lower in tumors with a high histologic grade than with a low histologic grade (P = 0.038) and with ER negativity than with ER positivity (P = 0.015). Triple-negative cancers showed a higher mean k(ep) than the luminal type (P = 0.015).CONCLUSION:Breast cancers with higher K(trans) and k(ep) , or lower v(e) , had poor prognostic factors and were often of the triple-negative subtype. | en_US |
dc.language.iso | en | en_US |
dc.publisher | John Wiley & Sons, Ltd | en_US |
dc.subject | dynamic contrast‐enhanced MRI | en_US |
dc.subject | breast cancer | en_US |
dc.subject | angiogenesis | en_US |
dc.subject | prognostic factors | en_US |
dc.title | Correlation of perfusion parameters on dynamic contrast-enhanced MRI with prognostic factors and subtypes of breast cancers | en_US |
dc.type | Article | en_US |
dc.relation.volume | 36 | - |
dc.identifier.doi | 10.1002/jmri.23635 | - |
dc.relation.page | 145-151 | - |
dc.relation.journal | JOURNAL OF MAGNETIC RESONANCE IMAGING | - |
dc.contributor.googleauthor | Koo, H. R. | - |
dc.contributor.googleauthor | Cho, N. | - |
dc.contributor.googleauthor | Song, I. C. | - |
dc.contributor.googleauthor | Kim, H. | - |
dc.contributor.googleauthor | Chang, J. M. | - |
dc.contributor.googleauthor | Yi, A. | - |
dc.contributor.googleauthor | Yun, B. L. | - |
dc.contributor.googleauthor | Moon, W. K. | - |
dc.relation.code | 2012233459 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | huilings | - |
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