Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 신원선 | - |
dc.date.accessioned | 2018-04-13T07:05:11Z | - |
dc.date.available | 2018-04-13T07:05:11Z | - |
dc.date.issued | 2011-12 | - |
dc.identifier.citation | JOURNAL OF ETHNOPHARMACOLOGY, NOV 18 2011, 138(2), p340-p344, 5p. | en_US |
dc.identifier.issn | 0378-8741 | - |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S0378874111005861 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/65856 | - |
dc.description.abstract | Ethnopharmacological relevanceRadix panax ginseng (Panax ginseng C.A. Meyer, Araliaceae, RPG) has been documented to possess hair growth activity and widely used to treat alopecia, while no report has been issued to date on the effect of Fructus panax ginseng (FPG) on hair regeneration.Materials and methodsTo investigate the effects of FPG extract on the proliferation of human hair dermal papilla cells (DPCs) and on the promotion of hair regeneration in C57BL6 mice, cell proliferation was evaluated in cultured DPC by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) and measured the expressions of Bcl-2 and Bax by immunoblot assay. We also compared the effects of topical FPG extract (1 and 10 mg/ml, 100 μl/d) with the effects of minoxidil as a positive control (5%, 100 μl/d) or vehicle control (30% ethanol) on the depilation-induced hair cycling in 7 week-old-C57BL/6 mice.ResultsFPG extract significantly increased the proliferation of DPCs in dose and time dependent manners (P < 0.05, P < 0.01 and P < 0.001). FPG extract also enhanced Bcl-2 expression and decreased Bax expression compared with control (P < 0.01). Moreover, significant elongations of anagen phase during hair cycle after application of FPG were evaluated by photographical and histological observations.ConclusionsFPG extract improves the cell proliferation of human DPCs through anti apoptotic activation. Topical administration of FPG extract might have hair regeneration activity for the treatment of hair loss. | en_US |
dc.description.sponsorship | The authors gratefully acknowledge Dr. Kangjin Lee for a counsel of experimental methods and also acknowledge professor Sung Kwon Ko for the verifying the components of FPG. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Elsevier Science B.V., Amsterdam. | en_US |
dc.subject | Fructus panax ginseng | en_US |
dc.subject | Dermal papilla cell | en_US |
dc.subject | Bcl-2Hair growth | en_US |
dc.subject | C57BL/6 | en_US |
dc.title | Fructus panax ginseng extract promotes hair regeneration in C57BL/6 mice | en_US |
dc.title.alternative | 6 mice | en_US |
dc.type | Article | en_US |
dc.relation.no | 2 | - |
dc.relation.volume | 138 | - |
dc.identifier.doi | 10.1016/j.jep.2011.08.013 | - |
dc.relation.page | 340-344 | - |
dc.relation.journal | JOURNAL OF ETHNOPHARMACOLOGY | - |
dc.contributor.googleauthor | Park, S. | - |
dc.contributor.googleauthor | Shin, W. S. | - |
dc.contributor.googleauthor | Ho, J. | - |
dc.relation.code | 2011205068 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF HUMAN ECOLOGY[S] | - |
dc.sector.department | DEPARTMENT OF FOOD & NUTRITION | - |
dc.identifier.pid | hime | - |
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