일개 농촌 인구 집단에서 고혈압과 비만이 심초음파로 측정한 좌심실비대 및 미세단백뇨에 미치는 영향

Abstract

Background: Both left ventricular hypertrophy (LVH) and microalbuminuria (MA) are well described markers or surrogate for cardiovascular outcome. Many factors are known to be related to the two markers which are encountered together in some patients. But the epidemiological backgrounds for the two markers are not clearly demonstrated so far. Methods:Measurements of echocardiographic left ventricular mass index (LVMI) and MA were introduced to the population survey in Yangpyeong County, Korea in 2005 and 2006 for 1,767 among 2,028 subjects. The criteria for MA were 17-250 mg/g of albumin creatinine ratio (ACR) in male and 25-355 mg/g in female. 1,636 data were analyzed. Results: Age was 60.9 ± 10.4years and the proportion of female was 59.4% (972). Body mass index (BMI) was 24.7 ± 3.21 kg/m'2 and blood pressure were 124.1 ± 17.3 mm Hg/80.0 ± 10.5 mm Hg. LVMI was 45.3 ± 11.6 g/m2.7 and ACR was 23.9 ± 150.9 mg/g. Prevalence of LVH and MA were 23.5% and 12.2%, respectively. In male/female, odds ratios for MA were 1.035 (range, 1.010-1.061)/1.01(range, 0.988-1.032) for age, 0.962 (range, 0.882-1.049)/0.941 (range, 0.881-1.006) for BMI, 1.754 (range, 1.097-2.804)/2.158 (range, 1.413-3.298) for hypertension (HTN), 4.87 (range, 2.883-8.226)/2.154 (range, 1.311-3.539) for diabetes, 1.005(range, 0.999-1.012)/1.007 (range, 1.002-1.012) for cholesterol, and 1.011 (range, 0.987-1.035)/1.011 (range, 0.994-1.029)for LVH. Conclusions: In a population level, even if diabetes was strongest factor for MA, HTN is also independent factor for MA in both genders.