Phage Display Screen for Peptides That Bind Bcl-2 Protein
- Title
- Phage Display Screen for Peptides That Bind Bcl-2 Protein
- Author
- 윤문영
- Keywords
- cancer; apoptosis; diagnostics probe; Bcl-2 protein-binding peptides; M13 phage display
- Issue Date
- 2011-01
- Publisher
- MARY ANN LIEBERT INC PUBL
- Citation
- JOURNAL OF BIOMOLECULAR SCREENING, v. 16, no. 1, Page. 82-89
- Abstract
- Bcl-2 family proteins are key regulators of apoptosis associated with human disease, including cancer. Bcl-2 protein has been found to be overexpressed in many cancer cells. Therefore, Bcl-2 protein is a potential diagnostic target for cancer detection. In the present study, the authors have identified several Bcl-2 binding peptides with high affinity (picomolar range) from a 5-round M13 phage display library screening. These peptides can be used to develop novel diagnostic probes or potent inhibitors with diverse polyvalencies. (Journal of Biomolecular Screening 2011:82-89)
- URI
- http://hdl.handle.net/20.500.11754/63566https://journals.sagepub.com/doi/10.1177/1087057110385816
- ISSN
- 1087-0571; 1552-454X
- DOI
- 10.1177/1087057110385816
- Appears in Collections:
- COLLEGE OF NATURAL SCIENCES[S](자연과학대학) > CHEMISTRY(화학과) > Articles
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