36 0

Adiposity, Adipokines, and Exhaled Nitric Oxide in Healthy Adults Without Asthma

Title
Adiposity, Adipokines, and Exhaled Nitric Oxide in Healthy Adults Without Asthma
Author
이창범
Issue Date
2011-08
Publisher
Informa Healthcare
Citation
The Journal of asthma, Feb 2011, 48,2, P.177-182
Abstract
Background. Epidemiological studies have shown that obesity//adiposity is closely associated with asthma in terms of development, severity, and control of asthma. However, effects of obesity//adiposity on airway inflammation are not well known in subjects without asthma. We assessed whether fractional exhaled nitric oxide (FeNO), a marker of eosinophilic airway inflammation, was associated with obesity//adiposity in nonasthmatic healthy adults. Methods. We measured FeNO and serum levels of adipose-derived hormones and adipokines in 117 adult subjects without a previous diagnosis of asthma or current asthmatic symptoms. Associations between FeNO and measures of obesity//adiposity [body mass index (BMI), body fat mass, and body fat percentages] were examined by correlation analyses and uni- and multivariate linear regression analyses. Results. FeNO was not significantly associated with BMI, body fat mass, or body fat percentage by a multivariate linear regression model, adjusting for age, gender, chronic rhinitis, atopy, and lung function. No significant association of FeNO with serum levels of leptin, adiponectin, tumor necrosis factor (TNF)-alpha alpha, or interleukin (IL)-6 was observed. Conclusions. These findings suggest that in healthy subjects without asthma, obesity//adiposity has no significant effect on eosinophilic airway inflammation and that hormones and systemic inflammation derived from adipose tissue do not affect eosinophilic airway inflammation.˂/.
URI
http://www.tandfonline.com/doi/abs/10.3109/02770903.2010.529223?journalCode=ijas20http://hdl.handle.net/20.500.11754/54871
ISSN
0277-0903; 1532-4303
DOI
10.3109/02770903.2010.52922310.3109/02770903.2010.529223
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE