211
0
Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | 박장환 | - |
| dc.date.accessioned | 2018-03-30T01:49:42Z | - |
| dc.date.available | 2018-03-30T01:49:42Z | - |
| dc.date.issued | 2014-08 | - |
| dc.identifier.citation | Stem cell reports, 2014, 3(2), P.353-364 | en_US |
| dc.identifier.issn | 2213-6711 | - |
| dc.identifier.uri | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4175555/ | - |
| dc.identifier.uri | http://hdl.handle.net/20.500.11754/54136 | - |
| dc.description.abstract | We here report that doxycycline, an antibacterial agent, exerts dramatic effects on human embryonic stem and induced pluripotent stem cells (hESC/iPSCs) survival and self-renewal. The survival-promoting effect was also manifest in cultures of neural stem cells (NSCs) derived from hESC/iPSCs. These doxycycline effects are not associated with its antibacterial action, but mediated by direct activation of a PI3K-AKT intracellular signal. These findings indicate doxycycline as a useful supplement for stem cell cultures, facilitating their growth and maintenance. | en_US |
| dc.description.sponsorship | This work was supported by grants from the Bio & Medical Technology Development Program (2010-0020232), the Medical Research Center (2008-0062190), and the basic science research program (2012R1A1-A3010261), funded by the National Research Foundation of Korea (NRF) of the Ministry of Education, Science and Technology (MEST), Republic of Korea and the research fund of Hanyang university (HY-2014). We appreciate Dr. Suresh Ramakrishna and Myungjae Song for their technical supports. | en_US |
| dc.language.iso | en | en_US |
| dc.publisher | CELL PRESS | en_US |
| dc.subject | DOPAMINE NEURONS | en_US |
| dc.subject | IN-VITRO | en_US |
| dc.subject | MICROGLIAL ACTIVATION | en_US |
| dc.subject | NEURAL PRECURSORS | en_US |
| dc.subject | HUMAN BLASTOCYSTS | en_US |
| dc.subject | RAT MODEL | en_US |
| dc.subject | DIFFERENTIATION | en_US |
| dc.subject | MINOCYCLINE | en_US |
| dc.subject | DERIVATION | en_US |
| dc.subject | ISCHEMIA | en_US |
| dc.title | Doxycycline enhances survival and self-renewal of human pluripotent stem cells | en_US |
| dc.type | Article | en_US |
| dc.relation.no | 2 | - |
| dc.relation.volume | 3 | - |
| dc.identifier.doi | 10.1016/j.stemcr.2014.06.013 | - |
| dc.relation.page | 353-364 | - |
| dc.relation.journal | Stem Cell Reports | - |
| dc.contributor.googleauthor | Chang, Mi-Yoon | - |
| dc.contributor.googleauthor | Rhee, Yong-Hee | - |
| dc.contributor.googleauthor | Yi, Sang-Hoon | - |
| dc.contributor.googleauthor | Lee, Su-Jae | - |
| dc.contributor.googleauthor | Kim, Rae-Kwon | - |
| dc.contributor.googleauthor | Kim, Hyongbum | - |
| dc.contributor.googleauthor | Park, Chang-Hwan | - |
| dc.contributor.googleauthor | Lee, Sang-Hun | - |
| dc.relation.code | 2014042071 | - |
| dc.sector.campus | S | - |
| dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
| dc.sector.department | DEPARTMENT OF MEDICINE | - |
| dc.identifier.pid | chshpark | - |
- Appears in Collections:
- COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
- Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
