Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김창렬 | - |
dc.date.accessioned | 2018-03-26T08:28:33Z | - |
dc.date.available | 2018-03-26T08:28:33Z | - |
dc.date.issued | 2014-09 | - |
dc.identifier.citation | ALLERGY ASTHMA & IMMUNOLOGY RESEARCH, 2014, 6(5), P.428-433 | en_US |
dc.identifier.issn | 2092-7355 | - |
dc.identifier.issn | 2092-7363 | - |
dc.identifier.uri | https://synapse.koreamed.org/DOIx.php?id=10.4168/aair.2014.6.5.428 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/52662 | - |
dc.description.abstract | Purpose: Mycoplasma pneumoniae pneumonia (MP) is associated with the exacerbation, timing, and onset of asthma. The goal of this study was to elucidate the impact of MP on eosinophil-related hyper-reactive amplification in atopic children. Methods: We studied 48 patients with MP (26 atopic, 22 non-atopic), between 3 and 12 years of age. Serial changes in blood eosinophil counts, serum interleukin-5 (IL-5), and serum eosinophil cationic protein (ECP) levels were measured in atopic and non-atopic children with MP upon admission, recovery, and at 2 months post-recovery. Serum IL-5 and ECP levels were measured by enzyme-linked immunosorbent assays; eosinophil counts were measured using an autoanalyzer. Results: Serial changes in serum IL-5, ECP, and total eosinophil counts were significantly higher in atopic patients, relative to non-atopic controls (P <= 0.001). Serum IL-5 and ECP levels were significantly higher in atopic patients at all three time points tested, while eosinophil counts were higher in the clinical recovery and follow-up phases, but not in the acute phase. Furthermore, among atopic patients, serum ECP levels were significantly higher in the recovery and follow-up phases than in the acute phase. Conclusions: The present study demonstrated significant differences in eosinophil counts, serum IL-5, and serum ECP levels between atopic and non-atopic children with MP at admission, recovery, and 2 months after clinical recovery. These outcomes are suggestive of eosinophil-related hyperreactivity in atopic children, with this status maintained for at least 2 months after MP. | en_US |
dc.description.sponsorship | This study was supported by the 2012 Hanyang University, College of Medicine, Research Fund (HY-201200000002835). | en_US |
dc.language.iso | en | en_US |
dc.publisher | KOREAN ACAD ASTHMA ALLERGY & CLINICAL IMMUNOLOGY, RM 1705, KUMHO BLDG 327-2, CHANGSINDONG, JONGNO-GU, SEOUL 110-540, SOUTH KOREA | en_US |
dc.subject | Eosinophil | en_US |
dc.subject | eosinophil cationic protein | en_US |
dc.subject | interleukin-5 | en_US |
dc.subject | pneumonia | en_US |
dc.subject | Mycoplasma pneumoniae | en_US |
dc.subject | atopy | en_US |
dc.subject | ALLERGIC AIRWAY INFLAMMATION | en_US |
dc.subject | ENDOTHELIAL GROWTH-FACTOR | en_US |
dc.subject | CATIONIC PROTEIN ECP | en_US |
dc.subject | MURINE MODEL | en_US |
dc.subject | BRONCHIAL HYPERRESPONSIVENESS | en_US |
dc.subject | ASTHMA | en_US |
dc.subject | INFECTION | en_US |
dc.subject | INTERLEUKIN-5 | en_US |
dc.subject | WHEEZE | en_US |
dc.subject | ADULTS | en_US |
dc.title | Serial Changes in Serum Eosinophil-associated Mediators between Atopic and Non-atopic Children after Mycoplasma pneumoniae pneumonia | en_US |
dc.type | Article | en_US |
dc.relation.no | 5 | - |
dc.relation.volume | 6 | - |
dc.identifier.doi | 10.4168/aair.2014.6.5.428 | - |
dc.relation.page | 428-433 | - |
dc.relation.journal | ALLERGY ASTHMA & IMMUNOLOGY RESEARCH | - |
dc.contributor.googleauthor | Kim, Joo-Hwa | - |
dc.contributor.googleauthor | Cho, Tae-Shik | - |
dc.contributor.googleauthor | Moon, Jin-Hwa | - |
dc.contributor.googleauthor | Kim, Chang-Ryul | - |
dc.contributor.googleauthor | Oh, Jae-Won | - |
dc.relation.code | 2014024562 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | crkim | - |
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