Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index
- Title
- Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index
- Author
- 김미경
- Keywords
- obesity; body mass index procedure; kvlqt1; genes; genome; single nucleotide polymorphism; genetics; asian; genome-wide association study
- Issue Date
- 2014-09
- Publisher
- Oxford University Press
- Citation
- Human Molecular Genetics, 2014, 23(20), P.5492?5504
- Abstract
- Recent genetic association studies have identified 55 genetic loci associated with obesity or body mass index (BMI). The vast majority, 51 loci, however, were identified in European-ancestry populations. We conducted a meta-analysis of associations between BMI and ∼2.5 million genotyped or imputed single nucleotide polymorphisms among 86 757 individuals of Asian ancestry, followed by in silico and de novo replication among 7488?47 352 additional Asian-ancestry individuals. We identified four novel BMI-associated loci near the KCNQ1 (rs2237892, P = 9.29 × 10?13), ALDH2/MYL2 (rs671, P = 3.40 × 10?11; rs12229654, P = 4.56 × 10?9), ITIH4 (rs2535633, P = 1.77 × 10?10) and NT5C2 (rs11191580, P = 3.83 × 10?8) genes. The association of BMI with rs2237892, rs671 and rs12229654 was significantly stronger among men than among women. Of the 51 BMI-associated loci initially identified in European-ancestry populations, we confirmed eight loci at the genome-wide significance level (P < 5.0 × 10?8) and an additional 14 at P < 1.0 × 10?3 with the same direction of effect as reported previously. Findings from this analysis expand our knowledge of the genetic basis of obesity.
- URI
- https://academic.oup.com/hmg/article/23/20/5492/2900672http://hdl.handle.net/20.500.11754/52168
- ISSN
- 0964-6906; 1460-2083
- DOI
- 10.1093/hmg/ddu248
- Appears in Collections:
- COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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