Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이항락 | - |
dc.date.accessioned | 2018-03-23T05:22:59Z | - |
dc.date.available | 2018-03-23T05:22:59Z | - |
dc.date.issued | 2014-03 | - |
dc.identifier.citation | GUT AND LIVER, Vol.8 No.2 [2014], pp. 140-147 | en_US |
dc.identifier.issn | 1976-2283 | - |
dc.identifier.issn | 2005-1212 | - |
dc.identifier.uri | http://www.gutnliver.org/journal/view.html?volume=8&number=2&spage=140&year=2014 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/51264 | - |
dc.description.abstract | Background/Aims: DA-9701, a standardized extract ofPharbitis Semen and Corydalis Tuber, is a new prokineticagent that exhibits an analgesic effect on the abdomen. Weinvestigated whether DA-9701 affects visceral pain inducedby colorectal distension (CRD) in rats.Methods: A total of21 rats were divided into three groups: group A (no CRD+nodrug), group B (CRD+no drug), and group C (CRD+DA-9701). Expression of pain-related factors, substance P (SP), c-fos,and phosphorylated extracellular signal-regulated kinase (p-ERK) in the dorsal root ganglion (DRG) and spinal cord wasdetermined by immunohistochemical staining and Westernblotting.Results: The proportions of neurons in the DRGand spinal cord expressing SP, c-fos, and p-ERK were higherin group B than in group A. In the group C, the proportion ofneurons in the DRG and spinal cord expressing p-ERK waslower than that in group B. Western blot results for p-ERK inthe spinal cord indicated a higher level of expression in groupB than in group A and a lower level of expression in group Cthan in group B.Conclusions: DA-9701 may decrease visceralpain via the downregulation of p-ERK in the DRG andspinal cord. | en_US |
dc.description.sponsorship | This study was supported by Dong-A Pharmaceutical Company, Seoul, Korea, the manufacturer of DA-9701. | en_US |
dc.language.iso | en | en_US |
dc.publisher | The Editorial Office of Gut and Liver | en_US |
dc.subject | DA-9701 | en_US |
dc.subject | Visceral hypersensitivity | en_US |
dc.subject | Visceral hypersensitivity | en_US |
dc.title | Effects of DA-9701, a Novel Prokinetic Agent, on Phosphorylated Extracellular Signal-Regulated Kinase Expression in the Dorsal Root Ganglion and Spinal Cord Induced by Colorectal Distension in Rats | en_US |
dc.type | Article | en_US |
dc.relation.no | 2 | - |
dc.relation.volume | 8 | - |
dc.identifier.doi | 10.5009/gnl.2014.8.2.140 | - |
dc.identifier.doi | 10.5009/gnl.2014.8.2.140 | - |
dc.relation.page | 140-147 | - |
dc.relation.journal | GUT AND LIVER | - |
dc.contributor.googleauthor | LeeLee, Sang-Pyo Sang-Pyo | - |
dc.contributor.googleauthor | LeeLee, Kang-Nyeong Kang-Nyeong | - |
dc.contributor.googleauthor | LeeLee, Oh-Young Oh-Young | - |
dc.contributor.googleauthor | LeeLee, Hang-Lak Hang-Lak | - |
dc.contributor.googleauthor | JunJun, Dae-Won Dae-Won | - |
dc.contributor.googleauthor | YoonYoon, Byung-Chul Byung-Chul | - |
dc.contributor.googleauthor | ChoiChoi, Ho-Soon Ho-Soon | - |
dc.contributor.googleauthor | HwangHwang, Se-Jin Se-Jin | - |
dc.contributor.googleauthor | LeeLee, Seo-Eun Seo-Eun | - |
dc.contributor.googleauthor | 이상표이상표 | - |
dc.contributor.googleauthor | 이강녕이강녕 | - |
dc.contributor.googleauthor | 이오영이오영 | - |
dc.contributor.googleauthor | 이항락이항락 | - |
dc.contributor.googleauthor | 전대원전대원 | - |
dc.contributor.googleauthor | 윤병철윤병철 | - |
dc.contributor.googleauthor | 최호순최호순 | - |
dc.contributor.googleauthor | 황세진황세진 | - |
dc.contributor.googleauthor | 이서은이서은 | - |
dc.relation.code | 2014030230 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | alwayshang | - |
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