Nasal and Exhaled Nitric Oxide in Allergic Rhinitis

Abstract

Objectives. The primary aim of this study was to assess whether one can use levels of nasal nitric oxide (nNO) and exhalednitric oxide (eNO) as a means of evaluation in allergic rhinitis.Methods. We used a chemiluminescence analyzer to measure nNO and eNO in normal controls (n=34) and allergic rhinitispatients (n=35), and compared these measurements with various parameters of clinical symptoms and laboratory data.Results. Mean nNO (389±119 ppb) in allergic rhinitis patients was significantly higher than normal controls (276±88 ppb).Without asthma, mean eNO (64.8±55.9 ppb) in allergic rhinitis patients was significantly higher than normal controls(33.0±24.0 ppb). In the persistent allergic rhinitis group, eNO concentration was significantly higher, while nNOconcentration was significantly lower than the intermittent group.Conclusion. We can use nNO and eNO levels for evaluation of allergic rhinitis. However, we should consider the fact thatnNO levels can be reduced, when symptoms are severe and long-lasting. Additionally, in allergic rhinitis, eNO can beelevated without asthma.