Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 엄애선 | - |
dc.date.accessioned | 2018-03-22T08:57:47Z | - |
dc.date.available | 2018-03-22T08:57:47Z | - |
dc.date.issued | 2014-11 | - |
dc.identifier.citation | 한국환경농학회지, 2014, 33(4), P.395-402 | en_US |
dc.identifier.issn | 1225-3537 | - |
dc.identifier.uri | http://www.korseaj.org/selectArticleInfo.do?article_a_no=HGNHB8_2014_v33n4_395&ano=HGNHB8_2014_v33n4_395 | - |
dc.description.abstract | BACKGROUND: Azadirachta indica Extract(AIE)containing azadirachtin as active ingredient have been usedworldwide as environment-friendly organic material havingpest control properties. However, the extracts prepared withdifferent solvent and from different plant site is very diverseand have different toxicity.METHODS AND RESULTS: In this study, the four weekrepeated oral dose toxicity test of aqueous AIE inSprague-Dawley rats was carried out to investigate the toxiceffect of liver, main toxicity target organ of AIE. The maleand female rats were divided into 4 groups, respectively;control(0 g/Kg bw), low-dose group(0.5 g/Kg bw),middle-dose(1.0 g/Kg bw) and high-dose group(2.0 g/Kgbw). As a results, relative liver weight increased withdose-dependent of AIE(p<0.05). Serum LDH in allAIE-treated groups were significantly lower than thecontrol in male rats(p<0.05). However, serum GOT andGPT were significantly increased in all male AIE-treatedgroups in male rats(p<0.05) and, in particular, increase ofserum GPT in dose-dependent manner raise the possibilityof liver damage. Even through serum GLU was increasedsignificantly in high-dose group in male rats compared tocontrol, there were no significant differences of urinary GLUamong all groups(p<0.05). In addition, histopathologicalexamination of the liver did not reveal any lesions in allAIE-treated groups.CONCLUSION: In conclusion, 4 weeks of the repeated oraladministration of AIE 2.0 g/Kg to rats has resulted no toxicresponse in liver. Therefore, AIE was no indicated to haveany toxic effect in the SD rats, when it was orallyadministrated below the dosage 2.0 g/Kg/day for 4weeks. | en_US |
dc.language.iso | ko_KR | en_US |
dc.publisher | The Korean Society Of Environmental Agriculture | en_US |
dc.subject | Azadirachta indica extract | en_US |
dc.subject | Hepatotoxicity | en_US |
dc.subject | Oral administration | en_US |
dc.subject | Rat | en_US |
dc.title | 수용성 님추출물이 랫드의 간 독성에 미치는 영향 | en_US |
dc.title.alternative | Effects of Aqueous Azadirachta indica Extract on Hepatotoxicity in Rats | en_US |
dc.type | Article | en_US |
dc.relation.no | 3 | - |
dc.relation.volume | 33 | - |
dc.identifier.doi | 10.5338/KJEA.2014.33.4.395 | - |
dc.relation.page | 267-274 | - |
dc.relation.journal | 한국환경농학회지 | - |
dc.contributor.googleauthor | 박경훈 | - |
dc.contributor.googleauthor | 윤현주 | - |
dc.contributor.googleauthor | 한범석 | - |
dc.contributor.googleauthor | 이제봉 | - |
dc.contributor.googleauthor | 정미혜 | - |
dc.contributor.googleauthor | 조남준 | - |
dc.contributor.googleauthor | 백민경 | - |
dc.contributor.googleauthor | Om, Aeson | - |
dc.relation.code | 2014001486 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF HUMAN ECOLOGY[S] | - |
dc.sector.department | DEPARTMENT OF FOOD & NUTRITION | - |
dc.identifier.pid | aesonom | - |
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