Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이양순 | - |
dc.date.accessioned | 2018-03-22T08:37:15Z | - |
dc.date.available | 2018-03-22T08:37:15Z | - |
dc.date.issued | 2014-10 | - |
dc.identifier.citation | FEMS microbiology letters v.359 no.2, | en_US |
dc.identifier.issn | 03781097 | - |
dc.identifier.issn | 1574-6968 | - |
dc.identifier.uri | http://academic.oup.com/femsle/article/359/2/144/2684111 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/50835 | - |
dc.description.abstract | Methicillin-resistant Staphylococcus aureus (MRSA) is an increasing cause of serious infection, both in the community and hospital settings. Despite sophisticated strategies and efforts, the antibiotic options for treating MRSA infection have been narrowed due to the limited number of newly developed antimicrobials. Herein, we analyze the completely sequenced genome of a novel virulent phage YMC/09/04/R1988 MRSA BP as a potential alternative anti-MRSA agent, which lysed clinical isolates from a patient admitted to the hospital due to hip disarticulation. The phage contains a linear double-stranded DNA genome of 44459bp in length, with 33.37% GC content, 62 predicted open reading frames (ORFs), and annotated functions of only 23 ORFs that are associated with structural assembly, host lysis, DNA replication, and modification. It showed a broad host range (17 of 30 strains) against MRSA strains in clinical isolates. | en_US |
dc.description.sponsorship | This research was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (NRF-2012R1A1A2009064) and by a grant from the Brain Korea 21 PLUS Project for Medical Science, Yonsei University. We are grateful to Ms. Sori Jong for technical assistance. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Oxford University Press | en_US |
dc.relation.ispartofseries | 2014년, pp.144 - 146; | - |
dc.subject | antibiotic resistant bacteria | en_US |
dc.subject | lytic bacteriophage | en_US |
dc.subject | alternative therapeutic agent | en_US |
dc.subject | infection | en_US |
dc.title | Complete genome sequence of the bacteriophage YMC/09/04/R1988 MRSA BP: a lytic phage from a methicillin-resistant Staphylococcus aureus isolate | en_US |
dc.title.alternative | 09 | en_US |
dc.type | Article | en_US |
dc.relation.no | 2 | - |
dc.relation.volume | 359 | - |
dc.identifier.doi | 10.1111/1574-6968.12580 | - |
dc.relation.page | 144-146 | - |
dc.relation.journal | FEMS MICROBIOLOGY LETTERS | - |
dc.contributor.googleauthor | Jeon, Jongsoo | - |
dc.contributor.googleauthor | D'Souza, Roshan | - |
dc.contributor.googleauthor | Hong, Sung Kuk | - |
dc.contributor.googleauthor | Lee, Yangsoon | - |
dc.contributor.googleauthor | Yong, Dongeun | - |
dc.contributor.googleauthor | Choi, Jongrak | - |
dc.contributor.googleauthor | Lee, Kyungwon | - |
dc.contributor.googleauthor | Chong, Yunsop | - |
dc.relation.code | 2014029586 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | yangsoon | - |
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