Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김혁 | - |
dc.date.accessioned | 2018-03-22T04:45:22Z | - |
dc.date.available | 2018-03-22T04:45:22Z | - |
dc.date.issued | 2013-01 | - |
dc.identifier.citation | The Korean Journal of Thoracic and Cardiovascular Surgery, 2013, 46(1), P.14-21 | en_US |
dc.identifier.issn | 2233-601X | - |
dc.identifier.issn | 2093-6516 | - |
dc.identifier.uri | http://www.kjtcvs.org/journal/view.html?volume=46&number=1&spage=14&year=2013 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/50436 | - |
dc.description.abstract | Background: Reactive oxygen species (ROS) are known to be related to cardiovascular diseases. Many studies have demonstrated that angiotensin-converting enzyme inhibitors have beneficial effects against ROS. We investigated the antioxidant effect of captopril and enalapril in nitric oxide mediated vascular endothelium-dependent relaxations. Materials and Methods: Isolated rabbit abdominal aorta ring segments were exposed to ROS by electrolysis of the organ bath medium (Krebs-Henseleit solution) after pretreatment with various concentrations (range, 10<SUP>-5</SUP> to 3×10<SUP>-4</SUP> M) of captopril and enalapril. Before and after electrolysis, the endothelial function was measured by preconstricting the vessels with norepinephrine (10<SUP>-6</SUP> M) followed by the cumulative addition of acetylcholine (range, 3×10<SUP>-8</SUP> to 10<SUP>-6</SUP> M). The relevance of the superoxide anion and hydrogen peroxide scavenging effect of captopril and enalapril was investigated using additional pretreatments of diethyldithiocarbamate (DETCA, 0.5 mM), an inhibitor of Cu/Zn superoxide dismutase, and 3-amino-1,2,4-triazole (3AT, 50 mM), an inhibitor of catalase. Results: Both captopril and enalapril preserved vascular endothelium-dependent relaxation after exposure to ROS in a dose-dependent manner (p<0.0001). Pretreatment with DETCA attenuated the antioxidant effect of captopril and enalapril (p< 0.0001), but pretreatment with 3AT did not have an effect. Conclusion: Both captopril and enalapril protect endothelium against ROS in a dose-dependent fashion in isolated rabbit abdominal aortas. This protective effect is related to superoxide anion scavenging. | en_US |
dc.language.iso | en | en_US |
dc.publisher | 대한흉부외과학회 | en_US |
dc.subject | Reactive oxygen species | en_US |
dc.subject | Angiotensin-converting enzyme inhibitors | en_US |
dc.subject | Captopril | en_US |
dc.subject | Enalapril | en_US |
dc.subject | Vasodilation | en_US |
dc.title | Antioxidant Effect of Captopril and Enalapril on Reactive Oxygen Species-Induced Endothelial Dysfunction in the Rabbit Abdominal Aorta | en_US |
dc.type | Article | en_US |
dc.relation.no | 1 | - |
dc.relation.volume | 46 | - |
dc.identifier.doi | 10.5090/kjtcs.2013.46.1.14 | - |
dc.relation.page | 14-21 | - |
dc.relation.journal | The Korean Journal of Thoracic and Cardiovascular Surgery | - |
dc.contributor.googleauthor | Kim, Ji Hoon | - |
dc.contributor.googleauthor | Kim, Hyuck | - |
dc.contributor.googleauthor | Kim, Young Hak | - |
dc.contributor.googleauthor | Chung, Won-Sang | - |
dc.contributor.googleauthor | Suh, Jung Kook | - |
dc.contributor.googleauthor | Kim, Sung Jin | - |
dc.relation.code | 2012285649 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | khkim | - |
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