Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 민경환 | - |
dc.date.accessioned | 2018-03-22T01:51:09Z | - |
dc.date.available | 2018-03-22T01:51:09Z | - |
dc.date.issued | 2013-08 | - |
dc.identifier.citation | KOREAN JOURNAL OF PATHOLOGY, 2013, 47(5), p.503 | en_US |
dc.identifier.issn | 1738-1843 | - |
dc.identifier.uri | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3759635/ | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/50281 | - |
dc.description.abstract | Background: ERG, a member of the ETS family of transcription factors, is a highly specific endothelial marker. We investigated whether the use of ERG immunostaining can help pathologists detect lymphovascular invasion (LVI) and decrease interobserver variability in LVI diagnosis. Methods: Fifteen cases of surgically resected colorectal cancers with hepatic metastasis were selected and the most representative sections for LVI detection were immunostained with ERG, CD31, and D2-40. Eight pathologists independently evaluated LVI status on hematoxylin and eosin (H&E) and the corresponding immunostained sections and then convened for a consensus meeting. The results were analyzed by kappa (κ) statistics. Results: The average rate of LVI positivity was observed in 43% with H&E only, 10% with CD31, 29% with D2-40, and 16% with ERG. Agreement among pathologists was fair for H&E only (κ=0.27), D2-40 (κ=0.21), ERG (κ=0.23), and was moderate for CD31 (κ=0.55). Consensus revealed that ERG nuclear immunoreactivity showed better visual contrast of LVI detection than the other staining, with improved agreement and LVI detection rate (κ=0.65, LVI positivity rate 80%). Conclusions: The present study demonstrated a superiority with ERG immunostaining and indicated that ERG is a promising panendothelial marker that might help pathologists increase LVI detection and decrease interobserver variability in LVI diagnosis. | en_US |
dc.description.sponsorship | This study was supported by Konkuk University 2013. | en_US |
dc.language.iso | en | en_US |
dc.publisher | 대한병리학회 | en_US |
dc.subject | CD31 | en_US |
dc.subject | ERG | en_US |
dc.subject | Lymphovascular invasion | en_US |
dc.subject | Endothelial marker | en_US |
dc.subject | Immunohistochemistry | en_US |
dc.title | ERG Immunohistochemistry as an Endothelial Marker for Assessing Lymphovascular Invasion | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.4132/KoreanJPathol.2013.47.5.503 | - |
dc.relation.journal | KOREAN JOURNAL OF PATHOLOGY | - |
dc.contributor.googleauthor | Kim, Sehun | - |
dc.contributor.googleauthor | Park, Hyung Kyu | - |
dc.contributor.googleauthor | Jung, Ho Young | - |
dc.contributor.googleauthor | Lee, So-Young | - |
dc.contributor.googleauthor | Min, Kyueng-Whan | - |
dc.contributor.googleauthor | Kim, Wook Youn | - |
dc.contributor.googleauthor | Han, Hye Seung | - |
dc.contributor.googleauthor | Kim, Wan Seop | - |
dc.contributor.googleauthor | Hwang, Tae Sook | - |
dc.contributor.googleauthor | Lim, So Dug | - |
dc.relation.code | 2013005803 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | kyueng | - |
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