Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김희진 | - |
dc.date.accessioned | 2018-03-20T02:41:11Z | - |
dc.date.available | 2018-03-20T02:41:11Z | - |
dc.date.issued | 2016-04 | - |
dc.identifier.citation | JOURNAL OF ALZHEIMERS DISEASE, v. 52, NO 3, Page. 1101-1109 | en_US |
dc.identifier.issn | 1387-2877 | - |
dc.identifier.issn | 1875-8908 | - |
dc.identifier.uri | https://content.iospress.com/articles/journal-of-alzheimers-disease/jad151197 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/49393 | - |
dc.description.abstract | Background: Rapid eye movement sleep behavior disorder (RBD) may present as an early manifestation of an evolving neurodegenerative disorder with alpha-synucleinopathy. Objective: We investigated that dementia with RBD might show distinctive cortical atrophic patterns. Methods: A total of 31 patients with idiopathic Parkinson's disease (IPD), 23 with clinically probable Alzheimer's disease (AD), and 36 healthy controls participated in this study. Patients with AD and IPD were divided into two groups according to results of polysomnography and rated with a validated Korean version of the RBD screening questionnaire (RBDSQ-K), which covers the clinical features of RBD. Voxel-based morphometry was adapted for detection of regional brain atrophy among groups of subjects. Results: Scores on RBDSQ-K were higher in the IPD group (3.54 +/- 2.8) than in any other group (AD, 2.94 +/- 2.4; healthy controls, 2.31 +/- 1.9). Atrophic changes according to RBDSQ-K scores were characteristically in the posterior part of the brain and brain stem, including the hypothalamus and posterior temporal region including the hippocampus and bilateral occipital lobe. AD patients with RBD showed more specialized atrophic patterns distributed in the posterior and inferior parts of the brain including the bilateral temporal and occipital cortices compared to groups without RBD. The IPD group with RBD showed right temporal cortical atrophic changes. Conclusion: The group of patients with neurodegenerative diseases and RBD showed distinctive brain atrophy patterns, especially in the posterior and inferior cortices. These results suggest that patients diagnosed with clinically probable AD or IPD might have mixed pathologies including alpha-synucleinopathy. | en_US |
dc.language.iso | en | en_US |
dc.publisher | IOS PRESS | en_US |
dc.subject | Brain atrophy | en_US |
dc.subject | dementia | en_US |
dc.subject | RBD screening questionnaire | en_US |
dc.subject | REM sleep disorder | en_US |
dc.subject | voxel-based morphometry | en_US |
dc.title | Brain Atrophy of Secondary REM-Sleep Behavior Disorder in Neurodegenerative Disease | en_US |
dc.type | Article | en_US |
dc.relation.no | 3 | - |
dc.relation.volume | 52 | - |
dc.identifier.doi | 10.3233/JAD-151197 | - |
dc.relation.page | 1101-1109 | - |
dc.relation.journal | JOURNAL OF ALZHEIMERS DISEASE | - |
dc.contributor.googleauthor | Kim, Hee-Jin | - |
dc.contributor.googleauthor | Im, Hyung Kyun | - |
dc.contributor.googleauthor | Kim, Juhan | - |
dc.contributor.googleauthor | Han, Jee-young | - |
dc.contributor.googleauthor | de Leon, Mony | - |
dc.contributor.googleauthor | Deshpande, Anup | - |
dc.contributor.googleauthor | Moon, Won-Jin | - |
dc.relation.code | 2016009110 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | hyumcbrain | - |
dc.identifier.orcid | http://orcid.org/0000-0001-7880-690X | - |
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