Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 최보율 | - |
dc.date.accessioned | 2018-03-19T07:12:51Z | - |
dc.date.available | 2018-03-19T07:12:51Z | - |
dc.date.issued | 2012-04 | - |
dc.identifier.citation | Diabetologia, Apr 2012, 55(4), P.981-995 | en_US |
dc.identifier.issn | 0012-186X | - |
dc.identifier.uri | https://link.springer.com/article/10.1007%2Fs00125-011-2370-7 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/49007 | - |
dc.description.abstract | FTO harbours the strongest known obesity-susceptibility locus in Europeans. While there is growing evidence for a role for FTO in obesity risk in Asians, its association with type 2 diabetes, independently of BMI, remains inconsistent. To test whether there is an association of the FTO locus with obesity and type 2 diabetes, we conducted a meta-analysis of 32 populations including 96,551 East and South Asians. All studies published on the association between FTO-rs9939609 (or proxy [r (2) ? 0.98]) and BMI, obesity or type 2 diabetes in East or South Asians were invited. Each study group analysed their data according to a standardised analysis plan. Association with type 2 diabetes was also adjusted for BMI. Random-effects meta-analyses were performed to pool all effect sizes. The FTO-rs9939609 minor allele increased risk of obesity by 1.25-fold/allele (p = 9.0 x 10(-19)), overweight by 1.13-fold/allele (p = 1.0 x 10(-11)) and type 2 diabetes by 1.15-fold/allele (p = 5.5 x 10(-8)). The association with type 2 diabetes was attenuated after adjustment for BMI (OR 1.10-fold/allele, p = 6.6 x 10(-5)). The FTO-rs9939609 minor allele increased BMI by 0.26 kg/m(2) per allele (p = 2.8 x 10(-17)), WHR by 0.003/allele (p = 1.2 x 10(-6)), and body fat percentage by 0.31%/allele (p = 0.0005). Associations were similar using dominant models. While the minor allele is less common in East Asians (12-20%) than South Asians (30-33%), the effect of FTO variation on obesity-related traits and type 2 diabetes was similar in the two populations. FTO is associated with increased risk of obesity and type 2 diabetes, with effect sizes similar in East and South Asians and similar to those observed in Europeans. Furthermore, FTO is also associated with type 2 diabetes independently of BMI. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Springer Science + Business Media | en_US |
dc.subject | Asians | en_US |
dc.subject | FTO | en_US |
dc.subject | Meta-analysis | en_US |
dc.subject | Obesity | en_US |
dc.subject | Type 2 diabetes | en_US |
dc.title | Association of genetic variation in FTO with risk of obesity and type 2 diabetes with data from 96,551 East and South Asians | en_US |
dc.type | Article | en_US |
dc.relation.no | 4 | - |
dc.relation.volume | 55 | - |
dc.identifier.doi | 10.1007/s00125-011-2370-7 | - |
dc.relation.page | 981-995 | - |
dc.relation.journal | DIABETOLOGIA | - |
dc.contributor.googleauthor | Li, H. | - |
dc.contributor.googleauthor | Kilpelainen, T. O. | - |
dc.contributor.googleauthor | Liu, C. | - |
dc.contributor.googleauthor | Zhu, J. | - |
dc.contributor.googleauthor | Liu, Y. | - |
dc.contributor.googleauthor | Hu, C. | - |
dc.contributor.googleauthor | Yang, Z. | - |
dc.contributor.googleauthor | Zhang, W. | - |
dc.contributor.googleauthor | Bao, W. | - |
dc.contributor.googleauthor | Cha, S. | - |
dc.relation.code | 2012202563 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | bychoi | - |
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