43 0

인후두 역류증의 약물요법에 적절한 약제 및 치료기간의 선택

Title
인후두 역류증의 약물요법에 적절한 약제 및 치료기간의 선택
Other Titles
Optimal Regimen and Period for the Treatment of Patients with Laryngopharyngeal Reflux Disease
Author
지용배
Keywords
Laryngopharyngeal reflux; Proton pump inhibitor; Reflux finding score; Reflux symptom index
Issue Date
2014-10
Publisher
대한이비인후과학회
Citation
대한이비인후과학회지, 2014, 57(10), P.698-702
Abstract
Background and ObjectivesVarious drugs can be used for treatment of laryngopharyngeal reflux disease (LPRD). However, the optimal medical treatment regimen is still controversial. This study was performed to determine the optimal medical treatment regimen and duration for LPRD.Subjects and MethodWe studied 172 patients who were diagnosed as LPRD by reflux symptom index (RSI) or reflux finding scores (RFS). The study group was divided into 4 groups according to the medication regimen: proton pump inhibitor (PPI), PPI and prokinetics, PPI and H2 blocker, and double dose PPI groups. All patients took medicines for 3 months or more. Clinical remission was defined as 70% improvement of initial RSI scores.Results36 (20.9%) patients were prescribed PPI only, 65 (37.8%) patients PPI with prokinetics, 51 (29.6%) patients PPI with H2 blocker, 20 (11.6%) patients double dose PPI. Pretreatment with RSI and RFS did not differ among the four groups. RSI was improved after one month of medication in all of the groups. RSI and RFS tended to decrease during the treatment in all groups (p for trend 〈0.001). The mean clinical remission time was 2.3 months in patients receiving PPI alone, 2.6 months in PPI and prokinetics group, 2.5 months in the PPI and H2 blocker group and 1.8 months in the double dose PPI group. About 70% of patients reached clinical remission within 3 months.ConclusionPPI with or without prokinetics or H2 blocker is effective treatment for LPRD, and the appropriate duration of medication seems to be about 3 months. Double dose PPI can be used for those whom normal dose PPI is ineffective.Korean J Otorhinolaryngol-Head Neck Surg 2014;57(10):698-702
URI
https://www.kci.go.kr/kciportal/ci/sereArticleSearch/ciSereArtiView.kci?sereArticleSearchBean.artiId=ART001921935http://hdl.handle.net/20.500.11754/48901
ISBN
2092-6529
ISSN
2092-5859
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE