Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김계성 | - |
dc.date.accessioned | 2018-03-16T02:44:22Z | - |
dc.date.available | 2018-03-16T02:44:22Z | - |
dc.date.issued | 2014-06 | - |
dc.identifier.citation | JOURNAL OF DENTAL RESEARCH, 2014, 93(6), P.571-575 | en_US |
dc.identifier.issn | 0022-0345 | - |
dc.identifier.issn | 1544-0591 | - |
dc.identifier.uri | http://journals.sagepub.com/doi/abs/10.1177/0022034514529303?journalCode=jdrb | - |
dc.description.abstract | MicroRNAs (miRNAs) are known to regulate a variety of gene functions in many tissues and organs, but their expression and function in tooth development are not well-understood. A specific miRNA, miR-135a, was determined to be highly expressed at the bud stage. Interestingly, after the cap stage, miR-135a was expressed in the epithelium and mesenchyme but not in the inner enamel epithelium. To identify the relationship between miR-135a and its putative target genes, Bmpr-Ia and Bmpr-Ib, in early tooth development, miR-135a was ectopically overexpressed with a lentivirus. This overexpression resulted in the repression of Bmpr-Ia and Bmpr-Ib. Furthermore, miR-135a inhibited both Bmpr-Ia and Bmpr-Ib transcription. BMP2 proteins were expressed ectopically in tooth germs during the cap stage to determine the relationship between miR-135a and BMP signaling in early tooth development. When miR-135a was ectopically expressed, no tooth formation was observed after 4 wk of incubation in the kidney capsule. This study suggested that Bmp signaling, specifically Bmpr-Ia and Bmpr-Ib, regulates tooth formation via miR-135a. | en_US |
dc.description.sponsorship | This study was supported by a grant from the Korean Health Technology R&D Project, Ministry of Health & Welfare, Republic of Korea (A101578). The authors declare no potential conflicts of interest with respect to the authorship and/or publication of this article. | en_US |
dc.language.iso | en | en_US |
dc.publisher | SAGE PUBLICATIONS INC | en_US |
dc.subject | microRNA | en_US |
dc.subject | Bmp receptors | en_US |
dc.subject | miRNA expression | en_US |
dc.subject | lentivirus | en_US |
dc.subject | miRNA inhibitor | en_US |
dc.subject | tooth development | en_US |
dc.title | Failure of Tooth Formation Mediated by miR-135a Overexpression via BMP Signaling | en_US |
dc.type | Article | en_US |
dc.relation.no | 6 | - |
dc.relation.volume | 93 | - |
dc.identifier.doi | 10.1177/0022034514529303 | - |
dc.relation.page | 571-575 | - |
dc.relation.journal | JOURNAL OF DENTAL RESEARCH | - |
dc.contributor.googleauthor | Kim, E.J | - |
dc.contributor.googleauthor | Lee, M.J. | - |
dc.contributor.googleauthor | Li, L. | - |
dc.contributor.googleauthor | Yoon, K.S. | - |
dc.contributor.googleauthor | Kim, K.S. | - |
dc.contributor.googleauthor | Jung, H.S | - |
dc.relation.code | 2014032925 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | ks66kim | - |
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