Expression of Liver X Receptor Correlates with Intrahepatic Inflammation and Fibrosis in Patients with Nonalcoholic Fatty Liver Disease
- Title
- Expression of Liver X Receptor Correlates with Intrahepatic Inflammation and Fibrosis in Patients with Nonalcoholic Fatty Liver Disease
- Author
- 장기석
- Keywords
- Liver X receptor; Nonalcoholic fatty liver disease; Nonalcoholic steatohepatitis; Hepatic fibrosis
- Issue Date
- 2014-08
- Publisher
- SPRINGER, VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
- Citation
- Digestive diseases and sciences, 2014, 59(12), pp. 2975-2982
- Abstract
- Liver X receptor (LXR) is an oxysterol-activated nuclear receptor involved in the control of major metabolic pathways for cholesterol homeostasis and lipogenesis. Although the role of LXR in hepatic steatosis is well known, its correlation with intrahepatic inflammation and fibrosis has not been thoroughly studied. We investigated the association between LXRα, hepatic inflammation, and fibrosis, as well as its correlation with other intrahepatic lipid transporters in patients with nonalcoholic fatty liver disease (NAFLD).
- URI
- http://link.springer.com/article/10.1007%2Fs10620-014-3289-xhttp://hdl.handle.net/20.500.11754/47261
- ISSN
- 0163-2116
- DOI
- 10.1007/s10620-014-3289-x
- Appears in Collections:
- COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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