The rise of biosimilars: potential benefits and drawbacks in rheumatoid arthritis
- Title
- The rise of biosimilars: potential benefits and drawbacks in rheumatoid arthritis
- Author
- 유대현
- Keywords
- affordability; biosimilar; immunogenicity; infliximab; microheterogeneity; rheumatoid arthritis; switching
- Issue Date
- 2014-08
- Publisher
- EXPERT REVIEWS, UNITEC HOUSE, 3RD FL, 2 ALBERT PLACE, FINCHLEY CENTRAL, LONDON N3 1QB, ENGLAND
- Citation
- EXPERT REVIEW OF CLINICAL IMMUNOLOGY, 2014 ,10(8), p981-983
- Abstract
- Although biologic agents are effective in the treatment of rheumatoid arthritis, the high price of drugs and restricted health care budgets have restricted easy access to biologics. Eventually, the use of biologic disease-modifying antirheumatic drugs might be inversely associated with disease activity in countries with low gross domestic product. The EMA approved an infliximab biosimilar for the first time in September 2013. The first approval of a biosimilar monoclonal antibody by a major regulatory authority provided a global standard for subsequent biosimilars and for biopharmaceutical companies developing biosimilars. Biosimilars with a highly similar quality and efficacy profile at an acceptable lower cost would significantly increase affordability of biologic disease-modifying antirheumatic drugs in the treatment of rheumatoid arthritis. Here, we will review the current status of first biosimilar antibody agent and the potential discussion points raised against biosimilars. In addition, the importance of awareness on biosimilars for stakeholders is discussed.
- URI
- https://www.tandfonline.com/doi/full/10.1586/1744666X.2014.932690http://hdl.handle.net/20.500.11754/47028
- ISSN
- 1744-666X
- DOI
- 10.1586/1744666X.2014.932690
- Appears in Collections:
- COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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