Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 박준성 | - |
dc.date.accessioned | 2018-03-14T07:11:23Z | - |
dc.date.available | 2018-03-14T07:11:23Z | - |
dc.date.issued | 2016-04 | - |
dc.identifier.citation | PLOS ONE, v. 11, NO 4, Page. 1-11 | en_US |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0153624#ack | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/46739 | - |
dc.description.abstract | Ferritin is considered to be a marker of the body's iron stores and has a potential relationship with the systemic manifestations of inflammatory reactions. Data on the association between increased levels of serum ferritin and ocular problems are limited, particularly in relation to age-related macular degeneration (AMD#. Serum ferritin levels, as a possible clinical parameter for predicting AMD, were analyzed in anthropometric, biochemical, and ophthalmologic data from a nation-wide, population-based, case-control study #KNHNES IV and V#. All native Koreans aged ˃= 20 years and who had no medical illness were eligible to participate. Among them, 2.9% had AMD, and its prevalence was found to increase in the higher ferritin quintile groups #P-trend ˂ 0.0001#. In multiple linear regression analysis, serum ferritin level was closely related to conventional risk factors for AMD. Comparison of early AMD with a control group showed that serum ferritin levels were closely associated with AMD #OR = 1.004, 95% CI = 1.002-1.006#, and further adjustment for age, gender, serum iron, and kidney function did not reduce this association #OR = 1.003, 95% CI = 1.001-1.006). Furthermore, the relationship between ferritin quintile and early AMD was dose-dependent. Thus, an increased level of serum ferritin in a healthy person may be a useful indicator of neurodegenerative change in the macula. A large population-based prospective clinical study is needed to confirm these findings. | en_US |
dc.language.iso | en | en_US |
dc.publisher | PUBLIC LIBRARY SCIENCE | en_US |
dc.subject | C-REACTIVE PROTEIN | en_US |
dc.subject | METABOLIC SYNDROME | en_US |
dc.subject | RISK-FACTORS | en_US |
dc.subject | KOREAN POPULATION | en_US |
dc.subject | DISEASE | en_US |
dc.subject | IRON | en_US |
dc.subject | NEURODEGENERATION | en_US |
dc.subject | PATHOGENESIS | en_US |
dc.subject | HEALTH | en_US |
dc.subject | CELLS | en_US |
dc.title | Association of Serum Ferritin and Kidney Function with Age-Related Macular Degeneration in the General Population | en_US |
dc.type | Article | en_US |
dc.relation.no | 4 | - |
dc.relation.volume | 11 | - |
dc.identifier.doi | 10.1371/journal.pone.0153624 | - |
dc.relation.page | 1-11 | - |
dc.relation.journal | PLOS ONE | - |
dc.contributor.googleauthor | Oh, Il Hwan | - |
dc.contributor.googleauthor | Choi, Eun Young | - |
dc.contributor.googleauthor | Park, Joon-Sung | - |
dc.contributor.googleauthor | Lee, Chang Hwa | - |
dc.relation.code | 2016007072 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | sjpjoon | - |
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