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Clinicopathologic Significance of Extranodal Tumor Extension in Colorectal Adenocarcinoma with Regional Lymph Node Metastasis

Title
Clinicopathologic Significance of Extranodal Tumor Extension in Colorectal Adenocarcinoma with Regional Lymph Node Metastasis
Author
백승삼
Keywords
CANCER PATIENTS; PROGNOSTIC-SIGNIFICANCE; EXTRACAPSULAR INVASION; GASTRIC-CANCER; CARCINOMA; SURVIVAL; BLADDER; SYSTEM; IMPACT; COLON
Issue Date
2016-04
Publisher
HINDAWI PUBLISHING CORP
Citation
GASTROENTEROLOGY RESEARCH AND PRACTICE, Page. 1-7
Abstract
Background.This study investigated the clinicopathologic significance of extranodal tumor extension in colorectal adenocarcinoma with lymph node metastasis. Method. Included were 419 patients who underwent curative resection for primary colorectal adenocarcinoma. Results. Extranodal tumor extension was observed more frequently in tumors with ulceroinfiltrative gross type (p = 0.026), higher histologic grade (p = 0.012), high grade tumor budding (p = 0.003), vascular invasion (p ˂ 0.001), perineural invasion (p = 0.015), tumor deposit (p ˂ 0.001), high ratio of metastatic/total lymph nodes (p ˂ 0.001), and high pN stage (p ˂ 0.001). Overall survival was significantly different between an extranodal tumor extension (-) group and an extranodal tumor extension (+) group for both N1 (p = 0.022) and N2 homogeneous staging (p = 0.007). Both overall (p = 0.002) and disease-free survival (p = 0.001) were significantly different between the two groups in an N1a homogeneous group and overall survival was significantly different (p = 0.016) in an N2b homogeneous group. Conclusion. Our study demonstrated that extranodal tumor extension was a useful prognostic factor for colorectal adenocarcinoma with lymph node metastasis, especially in homogeneous pN staging groups.
URI
https://www.hindawi.com/journals/grp/2016/5620765/http://hdl.handle.net/20.500.11754/46710
ISSN
1687-6121; 1687-630X
DOI
10.1155/2016/5620765
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COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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