The dose effect of ephedrine on the onset time and intubating conditions after cisatracurium administration
- Title
- The dose effect of ephedrine on the onset time and intubating conditions after cisatracurium administration
- Author
- 김교상
- Keywords
- Cisatracurium; Ephedrine; Hemodynamics; Intubation
- Issue Date
- 2014-07
- Publisher
- LIPPINCOTT WILLIAMS & WILKINS
- Citation
- Korean J Anesthesiol, 2014, 67(1), P.26-31
- Abstract
- BackgroundThe aim of this randomized, double-blind, placebo-controlled study was to evaluate dose effects of ephedrine pretreatment on the onset time and intubating conditions after cisatracurium administration.MethodsA total of 140 adult patients were randomized into 4 groups to receive either 30 μg/kg ephedrine (Group 30, n = 35), 70 μg/kg ephedrine (Group 70, n = 35), 110 μg/kg ephedrine (Group 110, n = 35), 3 ml normal saline (Group C, n = 35) as pretreatment given 30 s before anesthetic induction. Neuromuscular block was achieved with 0.15 mg/kg cisatracurium, evaluated accelomyographically with train-of-four stimulation. An anesthesiologist blinded to patient grouping assessed the intubating conditions 1.5 min after cisatracurium administration.ResultsAn onset time of 70 s was obtained in the ephedrine groups (Group 30: 155.4 ± 44.7 s, Group 70: 152.6 ± 40.3 s, Group 110: 151.2 ± 51.6 s) compared to Group C (224.6 ± 56.9 s) after 0.15 mg/kg of cisatracurium (P < 0.001). Ephedrine doses of either 70 or 110 μg/kg for pretreatment significantly improved intubating conditions (P < 0.05). Systolic and diastolic blood pressure and heart rate at 1 min after tracheal intubation were significantly increased than other times in all groups (P < 0.001), with no differences among the groups. However, 5 patients in Group 110 experienced marked hypertension (systolic/diastolic blood pressure: > 200/100 mmHg) 1 min after tracheal intubation with no patients in other groups.ConclusionsWe conclude that pre-treatment with ephedrine 70 μg/kg improved intubating conditions 1.5 min after cisatracurium administration and facilitated the onset of neuromuscular block (70 s) without adverse hemodynamic effects.
- URI
- https://synapse.koreamed.org/DOIx.php?id=10.4097/kjae.2014.67.1.26http://hdl.handle.net/20.500.11754/46450
- ISSN
- 2005-6419; 2005-7563
- DOI
- 10.4097/kjae.2014.67.1.26
- Appears in Collections:
- COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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