Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 박용욱 | - |
dc.date.accessioned | 2018-03-13T16:17:16Z | - |
dc.date.available | 2018-03-13T16:17:16Z | - |
dc.date.issued | 2013-12 | - |
dc.identifier.citation | Medical Molecular Morphology, Vol.46, No.4 [2013], p225?232 | en_US |
dc.identifier.issn | 1860-1480 | - |
dc.identifier.uri | http://link.springer.com/article/10.1007/s00795-013-0028-x | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/46369 | - |
dc.description.abstract | Acquired cystic disease-associated renal cell carcinoma (ACD-RCC) is a subtype of renal cell carcinoma (RCC) with unique morphologic features found exclusively in the background of end-stage renal disease. We analyzed the clinicopathologic features and immumoreactive profiles of 12 cases of ACD-RCC to further characterize this recently recognized entity. Review of histologic slides was performed in conjunction with immunohistochemical staining directed to the contemporary diagnostic antibodies and the putative target therapy-related markers. Histologically, the tumors showed characteristic inter-or intracellular microlumens and eosinophilic tumor cells. Intratumoral hemosiderin deposition and degenerating foamy tumor cells were consistent findings which were not previously described. Immunohistochemically, all the tumors were positive for alpha-methylacyl-CoA-racemase, CD10, pan-cytokeratin, PTEN (phosphatase and tensin homolog deleted on chromosome 10) and c-met, while negative for carbonic anhydrase-9, CD57, CD68, c-kit, pax-2, platelet-derived growth factor receptor (PDGFR)-α or vascular endothelial growth factor receptor (VEGFR)-2. Heterogenous staining was found for CK7 and kidney-specific cadherin. Positive reaction to c-met suggests its utility as a plausible therapeutic target in ACD-RCC. Thus, we present the unique morphologic and immunopathologic features of ACD-RCC, which may be helpful in both diagnostic and therapeutic aspects. | en_US |
dc.description.sponsorship | This work was supported by the Korean Society of Pathologists. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Springer Science + Business Media | en_US |
dc.subject | Acquired cystic disease | en_US |
dc.subject | Renal cell carcinoma | en_US |
dc.subject | c-met | en_US |
dc.subject | Target therapy | en_US |
dc.title | Acquired cystic disease-associated renal cell carcinoma: further characterization of the morphologic and immunopathologic features | en_US |
dc.type | Article | en_US |
dc.relation.volume | 46 | - |
dc.identifier.doi | 10.1007/s00795-013-0028-x | - |
dc.relation.page | 225-232 | - |
dc.relation.journal | MEDICAL MOLECULAR MORPHOLOGY | - |
dc.contributor.googleauthor | Ahn, S. | - |
dc.contributor.googleauthor | Kwon, G. Y. | - |
dc.contributor.googleauthor | Cho, Y. M. | - |
dc.contributor.googleauthor | Jun, S. Y. | - |
dc.contributor.googleauthor | Choi, C. | - |
dc.contributor.googleauthor | Kim, H. J. | - |
dc.contributor.googleauthor | Park, Y. W. | - |
dc.contributor.googleauthor | Park, W. S. | - |
dc.contributor.googleauthor | Shim, J. W. | - |
dc.relation.code | 2013006105 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | parkyu | - |
dc.identifier.researcherID | 7405375171 | - |
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